Risk Factors for Interstage Mortality Following the Norwood Procedure: Impact of Sociodemographic Factors

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• 作者：Laura C. Taylor ; Brendan Burke ; Janet E. Donohue ; Sunkyung Yu…
• 关键词：Interstage mortality ; Hypoplastic left ventricle ; Norwood ; Sociodemographic
• 刊名：Pediatric Cardiology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：37
• 期：1
• 页码：68-75
• 全文大小：502 KB
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• 作者单位：Laura C. Taylor (1) (6)
  Brendan Burke (2)
  Janet E. Donohue (3)
  Sunkyung Yu (3)
  Jennifer C. Hirsch-Romano (4)
  Richard G. Ohye (4)
  Caren S. Goldberg (5)
  
  1. Department of Pediatrics, C. S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA
  6. Department of Internal Medicine and Pediatrics, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-4204, USA
  2. Michigan State University College of Osteopathic Medicine, East Lansing, MI, USA
  3. Department of Pediatrics, M-CHORD (Michigan Congenital Heart Outcomes Research and Discovery), C. S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA
  4. Department of Pediatric Cardiac Surgery, C. S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA
  5. Division of Pediatric Cardiology, Department of Pediatrics, C. S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Cardiac Surgery
  Vascular Surgery
  
• 出版者：Springer New York
• ISSN：1432-1971

文摘

Interstage mortality remains significant for patients undergoing staged palliation for hypoplastic left heart syndrome and other related single right ventricle malformations (HLV). The purpose of this study was to identify factors related to demographics, socioeconomic position, and perioperative course associated with post-Norwood hospital discharge, pre-stage 2, interstage mortality (ISM). Medical record review was conducted for patients with HLV, born from 1/2000 to 7/2009 and discharged alive following the Norwood procedure. Sociodemographic and perioperative factors were reviewed. Patients were determined to have ISM if they died between Norwood procedure hospital discharge and stage 2 palliation. Univariable and multivariable logistic regressions were performed to identify risk factors associated with ISM. A total of 273 patients were included in the analysis; ISM occurred in 32 patients (12 %). Multivariable analysis demonstrated that independent risk factors for interstage mortality included teen mothers [adjusted odds ratio (AOR) 6.6, 95 % confidence interval (CI) 1.9–22.5], single adult caregivers (AOR 4.1, 95 % CI 1.2–14.4), postoperative dysrhythmia (AOR 2.7, 95 % CI 1.1–6.4), and longer ICU stay (AOR 2.7, 95 % CI 1.2–6.1). Anatomic and surgical course variables were not associated with ISM in multivariable analysis. Patients with HLV are at increased risk of ISM if born to a teen mother, if they lived in a home with only one adult caregiver, suffered a postoperative dysrhythmia, or experienced a prolonged ICU stay. These risk factors are identifiable, and thus these infants may be targeted for interventions to reduce ISM. Keywords Interstage mortality Hypoplastic left ventricle Norwood Sociodemographic