Human telomerase inhibitors from microbial source

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• 作者：Kalarikkal Gopikrishnan Kiran…
• 关键词：Anticancer ; Actinomycetes ; Catalytic subunit ; Ligands
• 刊名：World Journal of Microbiology & Biotechnology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：31
• 期：9
• 页码：1329-1341
• 全文大小：961 KB
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• 作者单位：Kalarikkal Gopikrishnan Kiran (1)
  Muthusamy Palaniswamy (2)
  Jayaraman Angayarkanni (1)
  
  1. Cancer Therapeutics Laboratory, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, India
  2. Department of Microbiology, Karpagam University, Coimbatore, 641021, India
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Applied Microbiology
  Biotechnology
  Biochemistry
  Environmental Biotechnology
  Microbiology
  
• 出版者：Springer Netherlands
• ISSN：1573-0972

文摘

Telomerase enzyme inhibitors have gained attention of scientific field due to the specificity of action of telomerase based therapies. Some telomerase have good combinatorial action with certain DNA damaging drugs. Natural compounds isolated from microbes provide a new scope of screening and large scale production of telomerase inhibitors. This review emphasizes the biochemistry and mode of action of different types of telomerase inhibitors isolated from microbial sources. Also elaborates on classification of telomerase inhibitors based on their mode of action in cancer cells.