No association between blood telomere length and longitudinally assessed diet or adiposity in a young adult Filipino population

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• 作者：Hilary J. Bethancourt ; Mario Kratz…
• 关键词：Telomere length ; Diet ; Nutrition ; Adiposity ; Nutrition transition
• 刊名：European Journal of Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：56
• 期：1
• 页码：295-308
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1293
• 卷排序：56

文摘

PurposeTelomeres, DNA–protein structures that cap and protect chromosomes, are thought to shorten more rapidly when exposed to chronic inflammation and oxidative stress. Diet and nutritional status may be a source of inflammation and oxidative stress. However, relationships between telomere length (TL) and diet or adiposity have primarily been studied cross-sectionally among older, overweight/obese populations and yielded inconsistent results. Little is known about the relationship between diet or body composition and TL among younger, low- to normal-weight populations. It also remains unclear how cumulative exposure to a specific diet or body composition during the years of growth and development, when telomere attrition is most rapid, may be related to TL in adulthood.