Investigation of the Relationship Between Oxidative Stress and Glucose Signaling in Schizosaccharomyces pombe

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• 作者：Bedia Palabiyik (1) bediag@istanbul.edu.tr
  Cenk Kig (12)
  Murat Pekmez (1)
  Levent Dalyan (1)
  Nazli Arda (1)
  Guler Temizkan (1)
• 关键词：Schizosaccharomyces pombe – ; Glucose signaling – ; Oxidative stress response – ; Glucose repression – ; Fission yeast
• 刊名：Biochemical Genetics
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：50
• 期：5-6
• 页码：336-349
• 全文大小：408.6 KB
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• 作者单位：1. Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Vezneciler, 34134 Istanbul, Turkey2. Department of Molecular Cell Biology, Catholic University of Leuven, 3000 Leuven, Belgium
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Biochemistry
  Zoology
  Medical Microbiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4927

文摘

The invertase mutant defective in the glucose signaling pathway of Schizosaccharomyces pombe (ird11) is resistant to glucose repression. This mutant is able to consume sucrose alongside glucose and grows in glucose-containing media with a generation time close to that of the wild type. Intracellular oxidation, protein carbonyl, and reduced glutathione levels and catalase, superoxide dismutase, and glutathione peroxidase activity were investigated in ird11, to determine the relationship between oxidative stress response and glucose signaling. The expression profiles of some genes involved in regulation of glucose repression (fbp1, fructose-1,6-bis-phosphatase; hxk2, hexokinase) and stress response (atf1 and pap1 transcription factors; ctt1, catalase; sod1, Cu,Zn superoxide dismutase) were analyzed using the quantitative real-time PCR technique. Oxidative stress response in ird11 seems to be affected by glucose signaling in a manner different from that caused by glucose deprivation.