Desensitization of menthol-activated cold receptors in lower extremities during local cooling in young women with a cold constitution

详细信息    查看全文

• 作者：Fumio Yamazaki ; Ryoko Sone
• 关键词：Cold sensation ; Cold receptor ; TRPM8 ; Skin blood flow ; Local temperature
• 刊名：The Journal of Physiological Sciences
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：67
• 期：2
• 页码：331-337
• 全文大小：
• 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
• 出版者：Springer Japan
• ISSN：1880-6562
• 卷排序：67

文摘

To test the hypothesis that topical menthol-induced reactivity of cold sensation and cutaneous vasoconstriction to local cooling is augmented in individuals with a cold constitution, we examined thermal sensation and cutaneous vasoconstrictor responses at menthol-treated and untreated sites in the legs during local skin cooling in young women complaining of chilliness (C group) and young women with no complaint as a normal control group (N group). During local skin cooling, the sensitivity to cold sensation was greater in the C group than in the N group. The application of menthol enhanced the cold sensation at a low temperature in the N group, but not in the C group. Cutaneous vasoconstrictor responses to local skin cooling were not altered by menthol treatment in either of the two groups. These findings suggest the desensitization of menthol-activated cold receptors in the legs of C group subjects, and a minor role of cold receptor activity in cutaneous vasoconstrictor response to local cooling.