The effects of physiological thermoregulation on the efficacy of surface cooling for therapeutic hypothermia

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• 作者：Mayank Kalra ; Majid Bahrami…
• 关键词：Induced hypothermia ; Body temperature regulation ; Computational modeling ; Surface cooling ; Vasoconstriction
• 刊名：Medical and Biological Engineering and Computing
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：53
• 期：3
• 页码：205-213
• 全文大小：980 KB
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• 作者单位：Mayank Kalra (1) (2)
  Majid Bahrami (1)
  Carolyn J. Sparrey (2) (3)
  
  1. Laboratory for Alternative Energy Conversion (LAEC), School of Mechatronic Systems Engineering, Simon Fraser University, 250-13450 102nd Avenue, Surrey, BC, V3T 0A3, Canada
  2. Neurospine Biomechanics Laboratory, School of Mechatronic Systems Engineering, Simon Fraser University, 250-13450 102nd Avenue, Surrey, BC, V3T 0A3, Canada
  3. International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre, 818 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada
  
• 刊物类别：Engineering
• 刊物主题：Biomedical Engineering
  Human Physiology
  Imaging and Radiology
  Computer Applications
  Neurosciences
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1741-0444

文摘

Therapeutic hypothermia is rapidly becoming an integral part of post-resuscitative care for post-cardiac arrest and neurotrauma patients. Despite the significant impact of thermoregulation on core temperature drop during rapid cooling, current mathematical models for thermoregulation have not been validated for hypothermic conditions. A geometrically accurate 3D model of an upper leg was developed by segmenting anatomical images from the visible human dataset into fat, muscle, bone, and blood vessels. Thermoregulation models from literature were implemented in the model. The numerical model results were compared with surface cooling experiments. There was a good agreement of simulation results with experimental data at 18?°C water immersion using existing models. However, at lower temperatures, the model parameter values needed to be significantly altered to account for cold-induced vasodilation in the superficial blood vessels and variation in muscle perfusion to match experimental observations. Additionally, results indicate that thermal mass has a dominant effect on cooling rate; therefore, uniform cooling over a large surface area will be more effective than targeted cooling of areas with superficial blood vessels. This study is the first to analyze the effects of thermoregulation in hypothermic conditions and identify unique thermoregulatory effects that differentiate hypothermic and normal conditions.