Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis

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• 作者：Tetsuhide Ito ; Hisato Igarashi ; Kazuhiko Nakamura…
• 关键词：Neuroendocrine tumor ; Pancreatic neuroendocrine tumor ; Gastrointestinal neuroendocrine tumor ; Nation ; wide survey ; Epidemiology
• 刊名：Journal of Gastroenterology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：50
• 期：1
• 页码：58-64
• 全文大小：206 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Oncology
  Surgical Oncology
  Hepatology
  Internal Medicine
  Colorectal Surgery
  
• 出版者：Springer Japan
• ISSN：1435-5922

文摘

Background Although neuroendocrine tumors (NETs) are rare, the number of patients with NET is increasing. However, in Japan, there have been no epidemiological studies on NET since 2005; thus, the prevalence of NET remains unknown. Methods We reported the epidemiology of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) [pancreatic neuroendocrine tumors (PNETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005. Here, we conducted the second nationwide survey on patients with GEP-NETs who received treatment in 2010. Results A total of 3,379 patients received treatment for PNETs in 2010, representing a 1.2-fold increase in the number of patients from 2005 to 2010. The prevalence was estimated to be 2.69/100,000, with an annual onset incidence of 1.27/100,000 in 2010. Non-functioning tumor (NF)-PNETs comprised 65.5?% of cases followed by insulinoma (20.9?%) and gastrinoma (8.2?%). Interestingly, the number of patients with NF-PNETs increased ~1.8 fold since 2005. A total of 19.9?% of patients exhibited distant metastasis at initial diagnosis; 4.3?% had complications with multiple endocrine neoplasia type 1 (MEN-1), and only 4.0?% had NF-PNETs associated with MEN-1. Meanwhile, an estimated 8,088 patients received treatment for GI-NETs, representing a ~1.8-fold increase since 2005. The prevalence was estimated to be 6.42/100,000, with an annual onset incidence of 3.51/100,000. The locations of GI-NETs varied: foregut, 26.1?%; midgut, 3.6?%; and hindgut, 70.3?%. Distant metastasis and complications with MEN-1 were observed in 6.0 and 0.42?% at initial diagnosis, respectively. The frequency of carcinoid syndrome in patients with GI-NETs was 3.2?%. Conclusion We clarified the epidemiological changes in GEP-NETs from 2005 to 2010 in Japan.