Acceptable pregnancy rate of unstimulated intrauterine insemination: a retrospective analysis of 17,830 cycles

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• 作者：Tetsuro Honda ; Mai Tsutsumi ; Fumio Komoda…
• 关键词：Controlled ovarian hyperstimulation ; Intrauterine insemination ; Multiple pregnancy ; Pregnancy rate ; Unstimulated
• 刊名：Reproductive Medicine and Biology
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：14
• 期：1
• 页码：27-32
• 全文大小：423 KB
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• 刊物主题：Reproductive Medicine; Gynecology; Urology/Andrology;
• 出版者：Springer Japan
• ISSN：1447-0578

文摘

Purpose To evaluate the pregnancy rate (PR) of unstimulated intrauterine insemination (IUI). Methods This was a retrospective study in a private fertility clinic. Between 2004 and 2013, a total of 4,045 women underwent 17,830 cycles of unstimulated IUI. The etiologies of subfertility in the couples were unexplained (51?%), male factor (36?%), coital problems (9.5?%), and cervical factor (3.5?%). Results The PRs/cycle, between the 1st and 9th trials, in women?42?years of age were 8.2, 7.3, 5.5, 3.6, and 0.9?%, respectively. In 10,076 cycles in which the male partner had a total motile sperm count???million, the PRs in the respective age groups were 9.9, 8.6, 6.1, 4.8, and 1.2?%. The largest-sized reported PRs for clomiphene citrate (CC)/IUI in the respective age groups were 11.5, 9.2, 7.3 4.3, and 1.0?% (4,199 cycles in total, Dovey et al., FertilSteril, 2008;90:2281-286). There were no significant differences in PRs between unstimulated IUI and CC/IUI. Conclusion PR for unstimulated IUI was similar to the reported PR for CC/IUI. Although this was a retrospective study without a control group, to reduce multiple pregnancy rate, we believe that unstimulated IUI is a reasonable treatment.