Self-Assembled and Nanostructured siRNA Delivery Systems

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• 作者：1. School of Pharmacy ; Sungkyunkwan University ; Suwon ; 440-46 South Korea2. Department of Biological Sciences Graduate School of Nanoscience and Technology ; Korea Advanced Institute of Science and Technology ; Daejeon ; 305-01 South Korea3. Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases ; Yonsei University Health System ; 250 Seongsanno ; Seodaemun-gu ; Seoul ; 120-752 South Korea
• 关键词：non ; viral gene carriers – PEGylated polyplex – self ; assembled nanostructures – siRNA medicines – siRNA ; PEG conjugates
• 刊名：Pharmaceutical Research
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：28
• 期：9
• 页码：2072-2085
• 全文大小：818.1 KB
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• 作者单位：http://www.springerlink.com/content/u31l627622250t71/
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X

文摘

A wide range of organic and inorganic materials have been used in the development of nano-scale self-assembling gene delivery systems to improve the therapeutic efficacy of nucleic acid drugs. Small interfering RNA (siRNA) has recently been recognized as a promising and potent nucleic acid medicine for the treatment of incurable genetic disorders including cancer; however, siRNA-based therapeutics suffer from the same delivery problems as conventional nucleic acid drugs such as plasmid DNA and antisense oligonucleotides. Many of the delivery strategies developed for nucleic acid drugs have been applied to siRNA therapeutics, but they have not produced satisfactory in vivo gene silencing efficiencies to warrant clinical trials. This review discusses recent progress in the development of self-assembled and nanostructured delivery systems for efficient siRNA-induced gene silencing and their potential application in clinical settings.