Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox

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• 作者：Susanne Beyer ; Aline Moosmann ; Astrid S. Kahnt ; Thomas Ulsh?fer…
• 关键词：biorelevant release ; Eudragit? RS 100 ; nanoparticles ; peroral drug delivery ; Ussing chamber
• 刊名：Pharmaceutical Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：32
• 期：12
• 页码：3986-3998
• 全文大小：1,319 KB
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• 作者单位：Susanne Beyer (1)
  Aline Moosmann (2)
  Astrid S. Kahnt (3)
  Thomas Ulsh?fer (4)
  Michael J. Parnham (4)
  Nerea Ferreirós (5)
  Sylvia Wagner (2)
  Matthias G. Wacker (1)
  
  1. Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt (Main), Germany
  2. Department of Bioprocess Technologies & Nanotechnology, Fraunhofer Institute for Biomedical Engineering, Ensheimer Stra?e 48, 66386, St. Ingbert, Germany
  3. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt (Main), Germany
  4. Fraunhofer Institute of Molecular Biology and Applied Ecology, Project Group for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596, Frankfurt (Main), Germany
  5. Institute of Clinical Pharmacology, Goethe University Hospital, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X

文摘

Purpose The contribution of permeability and drug release to drug targeting were investigated in the course of development of a nanosized formulation of the anti-inflammatory compound TMP-001, for the local treatment in the gastrointestinal tract.