Role of biomarkers in assessment of early infarct size after successful p-PCI for STEMI

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• 作者：Gert Klug (1)
  Agnes Mayr (1)
  Johannes Mair (1)
  Michael Schocke (2)
  Michael Nocker (1)
  Thomas Trieb (2)
  Werner Jaschke (2)
  Otmar Pachinger (1)
  Bernhard Metzler (1)
  
• 关键词：Primary PCI ; Myocardial infarction ; Creatine kinase ; Troponin ; Cardiac magnetic resonance
• 刊名：Clinical Research in Cardiology
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：100
• 期：6
• 页码：501-510
• 全文大小：296KB
• 参考文献：1. Miller TD, Christian TF, Hopfenspirger MR, Hodge DO, Gersh BJ, Gibbons RJ (1995) Infarct size after acute myocardial infarction measured by quantitative tomographic 99mtc sestamibi imaging predicts subsequent mortality. Circulation 92(3):334-41
  2. Becker LC, Silverman KJ, Bulkley BH, Kallman CH, Mellits ED, Weisfeldt M (1983) Comparison of early thallium-201 scintigraphy and gated blood pool imaging for predicting mortality in patients with acute myocardial infarction. Circulation 67(6):1272-282
  3. Gibbons RJ, Valeti US, Araoz PA, Jaffe AS (2004) The quantification of infarct size. J Am Coll Cardiol 44(8):1533-542. doi:10.1016/j.jacc.2004.06.071 CrossRef
  4. Ibrahim T, Nekolla SG, Hornke M, Bulow HP, Dirschinger J, Schomig A, Schwaiger M (2005) Quantitative measurement of infarct size by contrast-enhanced magnetic resonance imaging early after acute myocardial infarction: comparison with single-photon emission tomography using tc99m-sestamibi. J Am Coll Cardiol 45(4):544-52. doi:10.1016/j.jacc.2004.10.058 CrossRef
  5. Thiele H, Kappl MJ, Conradi S, Niebauer J, Hambrecht R, Schuler G (2006) Reproducibility of chronic and acute infarct size measurement by delayed enhancement-magnetic resonance imaging. J Am Coll Cardiol 47(8):1641-645. doi:10.1016/j.jacc.2005.11.065 CrossRef
  6. Kim RJ, Fieno DS, Parrish TB, Harris K, Chen EL, Simonetti O, Bundy J, Finn JP, Klocke FJ, Judd RM (1999) Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100(19):1992-002
  7. Ohman EM, Armstrong PW, White HD, Granger CB, Wilcox RG, Weaver WD, Gibler WB, Stebbins AL, Cianciolo C, Califf RM, Topol EJ (1999) Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. Gustoiii investigators. Global use of strategies to open occluded coronary arteries. Am J Cardiol 84(11):1281-286 CrossRef
  8. James SK, Armstrong P, Barnathan E, Califf R, Lindahl B, Siegbahn A, Simoons ML, Topol EJ, Venge P, Wallentin L (2003) Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a Gusto-IV Substudy. J Am Coll Cardiol 41(6):916-24. doi:S0735109702029698[pii] CrossRef
  9. Savonitto S, Granger CB, Ardissino D, Gardner L, Cavallini C, Galvani M, Ottani F, White HD, Armstrong PW, Ohman EM, Pieper KS, Califf RM, Topol EJ (2002) The prognostic value of creatine kinase elevations extends across the whole spectrum of acute coronary syndromes. J Am Coll Cardiol 39(1):22-9. doi:S0735109701017065[pii] CrossRef
  10. Nienhuis MB, Ottervanger JP, de Boer MJ, Dambrink JH, Hoorntje JC, Gosselink AT, Suryapranata H, van’t Hof AW (2008) Prognostic importance of creatine kinase and creatine kinase-MB after primary percutaneous coronary intervention for ST-elevation myocardial infarction. Am Heart J 155(4):673-79. doi:S0002-8703(07)00909-X[pii]10.1016/j.ahj.2007.11.004 CrossRef
  11. Grande P, Hansen BF, Christiansen C, Naestoft J (1982) Estimation of acute myocardial infarct size in man by serum CK-MB measurements. Circulation 65(4):756-64
  12. Metzler B, Hammerer-Lercher A, Jehle J, Dietrich H, Pachinger O, Xu Q, Mair J (2002) Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction. Clin Chim Acta 325(1-):87-0. doi:S0009898102002966[pii] CrossRef
  13. Cummins B, Cummins P (1987) Cardiac specific troponin-i release in canine experimental myocardial infarction: development of a sensitive enzyme-linked immunoassay. J Mol Cell Cardiol 19(10):999-010. doi:S0022-2828(87)80572-2[pii] CrossRef
  14. Costa TN, Cassaro Strunz CM, Nicolau JC, Gutierrez PS (2008) Comparison of MB fraction of creatine kinase mass and troponin I serum levels with necropsy findings in acute myocardial infarction. Am J Cardiol 101(3):311-14. doi:S0002-9149(07)01911-X[pii]10.1016/j.amjcard.2007.08.037 CrossRef
  15. Licka M, Zimmermann R, Zehelein J, Dengler TJ, Katus HA, Kubler W (2002) Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size. Heart 87(6):520-24 CrossRef
  16. Tzivoni D, Koukoui D, Guetta V, Novack L, Cowing G (2008) Comparison of troponin T to creatine kinase and to radionuclide cardiac imaging infarct size in patients with ST-elevation myocardial infarction undergoing primary angioplasty. Am J Cardiol 101(6):753-57. doi:S0002-9149(07)02221-7[pii]10.1016/j.amjcard.2007.09.119 CrossRef
  17. Chia S, Senatore F, Raffel OC, Lee H, Wackers FJ, Jang IK (2008) Utility of cardiac biomarkers in predicting infarct size, left ventricular function, and clinical outcome after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 1(4):415-23. doi:S1936-8798(08)00254-9[pii]10.1016/j.jcin.2008.04.010 CrossRef
  18. Wagner A, Mahrholdt H, Holly TA, Elliott MD, Regenfus M, Parker M, Klocke FJ, Bonow RO, Kim RJ, Judd RM (2003) Contrast-enhanced MRI and routine single photon emission computed tomography (spect) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet 361(9355):374-79. doi:S0140-6736(03)12389-6[pii]10.1016/S0140-6736(03)12389-6 CrossRef
  19. Steen H, Futterer S, Merten C, Junger C, Katus HA, Giannitsis E (2007) Relative role of NT-pro BNP and cardiac troponin T at 96 hours for estimation of infarct size and left ventricular function after acute myocardial infarction. J Cardiovasc Magn Reson 9(5):749-58. doi:782025879[pii]10.1080/10976640701544589 CrossRef
  20. Steen H, Giannitsis E, Futterer S, Merten C, Juenger C, Katus HA (2006) Cardiac troponin T at 96 hours after acute myocardial infarction correlates with infarct size and cardiac function. J Am Coll Cardiol 48(11):2192-194. doi:S0735-1097(06)01459-8[pii]10.1016/j.jacc.2006.06.002 CrossRef
  21. Haase J, Bayar R, Hackenbroch M, Storger H, Hofmann M, Schwarz CE, Reinemer H, Schwarz F, Ruef J, Sommer T (2004) Relationship between size of myocardial infarctions assessed by delayed contrast-enhanced MRI after primary PCI, biochemical markers, and time to intervention. J Interv Cardiol 17(6):367-73. doi:JOIC4078[pii]10.1111/j.1540-8183.2004.04078.x CrossRef
  22. Giannitsis E, Steen H, Kurz K, Ivandic B, Simon AC, Futterer S, Schild C, Isfort P, Jaffe AS, Katus HA (2008) Cardiac magnetic resonance imaging study for quantification of infarct size comparing directly serial versus single time-point measurements of cardiac troponin T. J Am Coll Cardiol 51(3):307-14. doi:S0735-1097(07)03442-0[pii]10.1016/j.jacc.2007.09.041 CrossRef
  23. Bohmer E, Hoffmann P, Abdelnoor M, Seljeflot I, Halvorsen S (2009) Troponin T concentration 3 days after acute ST-elevation myocardial infarction predicts infarct size and cardiac function at 3?months. Cardiology 113(3):207-12. doi:00020199[pii]10.1159/000201991 CrossRef
  24. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined—a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36(3):959-69. doi:S0735109700008044[pii] CrossRef
  25. Mayr A, Mair J, Schocke M, Klug G, Pedarnig K, Haubner BJ, Nowosielski M, Grubinger T, Pachinger O, Metzler B (2009) Predictive value of NT-pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function. Int J Cardiol. doi: 10.1016/j.ijcard.2009.09.537
  26. Matthews JN, Altman DG, Campbell MJ, Royston P (1990) Analysis of serial measurements in medical research. BMJ 300(6719):230-35 CrossRef
  27. Klug G, Trieb T, Schocke M, Nocker M, Skalla E, Mayr A, Nowosielski M, Pedarnig K, Bartel T, Moes N, Pachinger O, Metzler B (2009) Quantification of regional functional improvement of infarcted myocardium after primary PTCA by contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 29(2):298-04. doi:10.1002/jmri.21498 CrossRef
  28. Beek AM, Kuhl HP, Bondarenko O, Twisk JW, Hofman MB, van Dockum WG, Visser CA, van Rossum AC (2003) Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. J Am Coll Cardiol 42(5):895-01. doi:S0735109703008350 CrossRef
  29. Bondarenko O, Beek AM, Hofman MB, Kuhl HP, Twisk JW, van Dockum WG, Visser CA, van Rossum AC (2005) Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR. J Cardiovasc Magn Reson 7(2):481-85 CrossRef
  30. Nowosielski M, Schocke M, Mayr A, Pedarnig K, Klug G, Kohler A, Bartel T, Muller S, Trieb T, Pachinger O, Metzler B (2009) Comparison of wall thickening and ejection fraction by cardiovascular magnetic resonance and echocardiography in acute myocardial infarction. J Cardiovasc Magn Reson 11(1):22. doi:1532-429X-11-22[pii]10.1186/1532-429X-11-22 CrossRef
  31. Gallegos RP, Swingen C, Xu XJ, Wang X, Bianco R, Jerosch-Herold M, Bolman RM 3rd (2004) Infarct extent by MRI correlates with peak serum troponin level in the canine model. J Surg Res 120(2):266-71. doi:10.1016/j.jss.2004.02.025 CrossRef
  32. Kurz K, Schild C, Isfort P, Katus HA, Giannitsis E (2009) Serial and single time-point measurements of cardiac troponin T for prediction of clinical outcomes in patients with acute ST-segment elevation myocardial infarction. Clin Res Cardiol 98(2):94-00. doi:10.1007/s00392-008-0727-9 CrossRef
  33. Kelle S, Roes SD, Klein C, Kokocinski T, de Roos A, Fleck E, Bax JJ, Nagel E (2009) Prognostic value of myocardial infarct size and contractile reserve using magnetic resonance imaging. J Am Coll Cardiol 54(19):1770-777. doi:S0735-1097(09)02668-0 CrossRef
  34. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348(14):1309-321. doi:10.1056/NEJMoa030207NEJMoa030207[pii] CrossRef
  35. Rasoul S, Nienhuis MB, Ottervanger JP, Slingerland RJ, de Boer MJ, Dambrink JH, Ernst NM, Hoorntje JC, Gosselink AT, Suryapranata H, Zijlstra F, van ‘t Hof AW (2006) Predictors of elevated cardiac troponin T on admission in ST-segment elevation myocardial infarction. Ann Clin Biochem 43(Pt 4):281-86. doi:10.1258/000456306777695627 CrossRef
  36. Panteghini M, Bonetti G, Pagani F, Stefini F, Giubbini R, Cuccia C (2005) Measurement of troponin I 48 h after admission as a tool to rule out impaired left ventricular function in patients with a first myocardial infarction. Clin Chem Lab Med 43(8):848-54. doi:10.1515/CCLM.2005.143 CrossRef
  37. Apple FS, Sharkey SW, Falahati A, Murakami M, Mitha N, Christensen D (1998) Assessment of left ventricular function using serum cardiac troponin I measurements following myocardial infarction. Clin Chim Acta 272(1):59-7. doi:S0009898197002520[pii] CrossRef
  38. Adams JE 3rd, Sicard GA, Allen BT, Bridwell KH, Lenke LG, Davila-Roman VG, Bodor GS, Ladenson JH, Jaffe AS (1994) Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I. N Engl J Med 330(10):670-74 CrossRef
  39. Suessenbacher A, Doerler J, Alber H, Aichinger J, Altenberger J, Benzer W, Christ G, Globits S, Huber K, Karnik R, Norman G, Siostrzonek P, Zenker G, Pachinger O, Weidinger F (2008) Gender-related outcome following percutaneous coronary intervention for ST-elevation myocardial infarction: Data from the Austrian Acute PCI Registry. EuroIntervention 4(2):271-76 CrossRef
  40. Wiviott SD, Cannon CP, Morrow DA, Murphy SA, Gibson CM, McCabe CH, Sabatine MS, Rifai N, Giugliano RP, DiBattiste PM, Demopoulos LA, Antman EM, Braunwald E (2004) Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: A Tactics-TIMI 18 (Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis in Myocardial Infarction 18) substudy. Circulation 109(5):580-86. doi:10.1161/01.CIR.0000109491.66226.26109/5/580[pii] CrossRef
  
• 作者单位：Gert Klug (1)
  Agnes Mayr (1)
  Johannes Mair (1)
  Michael Schocke (2)
  Michael Nocker (1)
  Thomas Trieb (2)
  Werner Jaschke (2)
  Otmar Pachinger (1)
  Bernhard Metzler (1)
  
  1. University Clinic of Internal Medicine III, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
  2. Department of Radiology I, Medical University of Innsbruck, Innsbruck, Austria
  

文摘

Objective The aim of the study was to find out if single time point and estimated cumulative release of cardiac troponin T (cTnT) and creatine kinase (CK) correlate with early infarct size and left ventricular function measured by cardiac magnetic resonance (CMR). Methods CMR and serial CK and cTnT measurements were performed in 103 patients (85 male, mean age 55.8?±?12.1 years) within at least 8 days (3.1?±?1.5 days) after first acute myocardial infarction and successful primary percutaneous coronary interventions. Infarct size was determined on delayed gadolinium-enhanced phase-sensitive IR-SSFP CMR sequences. Single time point, peak and cumulative cardiac protein release were correlated with infarct size. Results All single time point, peak and estimated cumulative release of CK and cTnT values except on admission showed significant correlations with infarct size. Among single time point values, cTnT after 96?h (cTnT96; r?=?0.680, p?<?0.001) and CK after 24?h (CK24; r?=?0.699, p?<?0.001) showed the closest correlations with infarct size. Peak CK and cTnT levels correlated only slightly better than single time point values (r?=?0.703 and 0.688, p?<?0.001), whereas cumulative release values did not show closer correlations than single point values. Receiver-operator characteristics analysis showed that cTnT96 and CK24 detected large infarct areas (>16.8?g) and decreased left ventricular function (EF?<?40%) with high sensitivity and specificity. Conclusion Both single time point cTnT concentrations and CK activities correlate well with infarct size early after primary PCI for STEMI. Cardiac TnT levels determined 3-?days after revascularization for acute myocardial infarction allow for a good estimation of acute infarct size as well as an approximation of LV function and morphology.