Evaluation of Fumagilin-B® and other potential alternative chemotherapies against Nosema ceranae-infected honeybees (Apis mellifera) in cage trial assays

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• 作者：Johan P. van den Heever ; Thomas S. Thompson ; Simon J. G. Otto…
• 关键词：Fumagilin ; B® ; fumagillin ; dicyclohexylamine ; DCH ; analogues ; apiculture
• 刊名：Apidologie
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：47
• 期：5
• 页码：617-630
• 全文大小：536 KB
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• 作者单位：Johan P. van den Heever (1)
  Thomas S. Thompson (1)
  Simon J. G. Otto (1) (2)
  Jonathan M. Curtis (3)
  Abdullah Ibrahim (4)
  Stephen F. Pernal (4)
  
  1. Alberta Agriculture and Forestry, Food Safety Division, Agri-Food Laboratories Branch, 6909-116 Street, Edmonton, Alberta, T6H 4P2, Canada
  2. School of Public Health, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada
  3. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada
  4. Agriculture and Agri-Food Canada, Beaverlodge Research Farm, P.O. Box 29, Beaverlodge, Alberta, T0H 0C0, Canada
  
• 刊物主题：Entomology; Life Sciences, general;
• 出版者：Springer Paris
• ISSN：1297-9678
• 卷排序：47

文摘

Fumagilin-B® is the only currently registered chemical treatment available to combat nosema disease in apiculture. Fumagillol, the basic hydrolysis product of fumagillin, two semisynthetic fumagillin analogues, and four in-house purely synthetic compounds which were designed to mimic the mode of action of fumagillin against the methionine aminopeptidase type 2 (MetAP-2) enzyme, was observed to exhibit statistically significant biological activity against Nosema ceranae-infected caged bees. None of these compounds were, however, as effective as Fumagilin-B®. The commercially available thymol and enilconazole also exhibited activity against N. ceranae, with thymol being the most promising chemical treatment other than Fumagilin-B®. High cumulative bee mortality was associated with the therapeutic dosage of Fumagilin-B® during our study, suggesting the need for continued investigation. Keywords Fumagilin-B® fumagillin dicyclohexylamine DCH analogues apiculture