Inflammatory myopathy with anti-SRP antibodies: case series of a South Australian cohort

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• 作者：Sajini K Basnayake (1)
  Peter Blumbergs (2)
  Ju Ann Tan (3)
  Peter J Roberts-Thompson (3) (4) (5)
  Vidya Limaye (1) (5)
  
  1. Rheumatology Department ; Royal Adelaide Hospital ; North Tce ; Adelaide ; SA ; 5000 ; Australia
  2. Department of Pathology ; University of Adelaide ; Adelaide ; Australia
  3. Immunology Department ; Flinders Medical Centre ; Bedford Park ; Australia
  4. Immunology Department ; SA Pathology ; Wayville ; Australia
  5. Department of Medicine ; Adelaide University ; Adelaide ; Australia
  
• 关键词：Histopathology ; Muscle biopsy ; Myositis ; Necrotizing myopathy ; Polymyositis ; SRP antibodies
• 刊名：Clinical Rheumatology
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：34
• 期：3
• 页码：603-608
• 全文大小：131 KB
• 参考文献：1. Karin, R, Frederick Miller, W, Bernhard, D, Stephen, H (2006) Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages. Arthritis Res Ther 8: pp. R39 CrossRef
  2. Kao, AH, Lacomis, D, Lucas, M, Fertig, N, Oddis, CV (2004) Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy. Arthritis Rheum 50: pp. 209-215 CrossRef
  3. Brouwer, R, Hengstman, GJ, Vree Egberts, W, Ehrfeld, H, Bozic, B, Ghirardello, A (2001) Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 60: pp. 116-123 CrossRef
  4. Targoff, IN, Johnson, AE, Miller, FW (1990) Antibody to signal recognition particle in polymyositis. Arthritis Rheum 33: pp. 1361-1370 CrossRef
  5. Miller, T, Al-Lozi, MT, Lopate, G, Pestronk, A (2002) Myopathy with antibodies to the signal recognition particle: clinical and pathological features. J Neurol Neurosurg Psychiatry 73: pp. 420-428 CrossRef
  6. Ira, N, Targoff, , Arthur Johnson, E, Frederick Miller, W (1990) Antibody to signal recognition particle in polymyositis. Arthritis Rheum 33: pp. 1361-1370 CrossRef
  7. Hengstman, GJ, Laak, HJ, Vree Egberts, WT, Lundberg, IE, Moutsopoulos, HM, Vencovsky, J (2006) Anti-SRP autoantibodies, marker of a necrotizing myopathy. Ann Rheum Dis 65: pp. 1635-1638 CrossRef
  8. Hengstman, GJ, Brouwer, R, Egberts, WT, Seelig, HP, Jongen, PJ, Venrooij, WJ (2002) Clinical and serological characteristics of 125 Dutch myositis patients: myositis specific autoantibodies aid in the differential diagnosis of the idiopathic inflammatory myopathies. J Neurol 249: pp. 69-75 CrossRef
  9. Love, LA, Leff, RL, Fraser, DD, Targoff, IN, Dalakas, M, Plotz, PH, Miller, FW (1991) A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous groups. Medicine 70: pp. 360-374 CrossRef
  10. Hausmanowa-Petrusewicz, I, Kowalska-Oledzka, E, Miller, FW, Jarzabek, CM, Targoff, IN, Blaszczyk, KM (1997) Clinical, serologic, and immunogenetic features in Polish patients with idiopathic inflammatory myopathy. Arthritis Rheum 40: pp. 1257-1266 CrossRef
  11. Benveniste O, Drouot L, Jouen F, Charuel JL, Bloch-Queyrat C, Behin A, Amoura Z, Marie I, Guiguet M, Eymard B, Gilbert D, Tron F, Herson S, Musset L, Boyer O (2011) Anti-signal recognition particle auto-antibody levels correlate with creatine kinase activity in patients with necrotizing myopathy. Arthritis Rheum
  12. Valiyil, R, Casciola-Rosen, L, Hong, G, Mammen, A, Christopher-Stine, L (2010) Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res 62: pp. 1328-1334 CrossRef
  13. Sultan, SM, Ng, KP, Edwards, JC, Isenberg, DA, Cambridge, G (2008) Clinical outcome following B cell depletion therapy in eight patients with refractory inflammatory myopathy. Clin Exp Rheumatol 26: pp. 887-893
  14. Hohlfeld, R Polymyositis and dermatomyositis. In: Karpati, G eds. (2002) Structural and molecular basis of skeletal muscle disease. ISN Neuropath Press, Switzerland, pp. 221-227
  15. Dalakas, MC (2011) Pathophysiology of inflammatory and autoimmune myopathies. Press Med 40: pp. e237-e247 CrossRef
  16. Chahin, N, Engel, AG (2008) Correlation of muscle biopsy, clinical course, and outcome in PM and sporadic IBM. Neurology 70: pp. 418-424 CrossRef
  17. Mastalgia, FL, Philips, VA (2002) Idiopathic inflammatory myopathies, epidemiology, classification and diagnostic criteria. Rheum Dis Clin North Am 28: pp. 723-741 CrossRef
  18. Suzuki, S, Satoh, T, Sato, S, Otomo, M, Hirayama, Y, Sato, H, Kawai, M, Ishihara, T, Suzuki, N, Kuwana, M (2008) Clinical utility of anti-signal recognition particle antibody in the differential diagnosis of myopathies. Rheumatology (Oxford) 47: pp. 1539-1542 CrossRef
  19. Benveniste, O, Drouot, L, Jouen, F, Charuel, JL, Bloch-Queyrat, C, Behin, A, Amoura, Z, Marie, I, Guiguet, M, Eymard, B, Gilbert, D, Tron, F, Herson, S, Musset, L, Boyer, O (2011) Correlation of anti-signal recognition particle autoantibody levels with creatine kinase activity in patients with necrotizing myopathy. Arthritis Rheum 63: pp. 1961-1971 CrossRef
  20. R枚nnelid, J, Barbasso Helmers, S, Storfors, H, Grip, K, R枚nnblom, L, Franck-Larsson, K, Nordmark, G, Lundberg, IE (2009) Use of a commercial line blot assay as a screening test for autoantibodies in inflammatory myopathies. Autoimmun Rev 9: pp. 58-61 CrossRef
  21. Ghirardello, A, Rampudda, ME, Bassi, N, Zampieri, S, Grypiotis, P, Bendo, R, Arienti, S, Tonon, G, Lundberg, IE, Doria, A (2008) Serological testing in myositis patients: diagnostic accuracy of a commercial line blot assay. 6. International Congress on Autoimmunity, Porto
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  
• 出版者：Springer London
• ISSN：1434-9949

文摘

Myopathy associated with anti-signal recognition particle (SRP) antibodies is a rare form of myopathy, which is thought to be distinct from classic polymyositis. We sought to determine the demographic, clinical and histopathological features of patients with anti-SRP antibodies. Hence we undertook an audit of patients with histologically-confirmed myositis who had anti-SRP antibodies. Of 144 patients with inflammatory myositis tested for myositis-specific and myositis-associated antibodies between 2007 and 2011 inclusive, five with anti-SRP antibodies were identified. All five were male, four had severe proximal weakness, one was asymptomatic and three had dysphagia. None had cardiovascular involvement. All patients showed isolated anti-SRP positivity and absence of antinuclear antibodies. Muscle histopathology showed variable myofibre necrosis, and most had an inflammatory infiltrate. Majority showed a favorable response to combination immunosuppressive therapy. Myopathy associated with anti-SRP antibodies is clinically heterogeneous in presentation. Muscle histopathology shows a mixture of necrotic and inflammatory features.