MRI and 18FDG-PET in the assessment of bone marrow infiltration of the spine in cancer patients

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• 作者：Nadir Alexander Ghanem ; Gregor Pache ; Christian Lohrmann ; Ingo Brink ; Thorsten Bley ; Elmar Kotter ; Thomas Kelly and Mathias Langer
• 关键词：Bone marrow infiltration ; Spine ; Lymphoma ; Solid tumour ; MRI ; 18FDG ; PET
• 刊名：European Spine Journal
• 出版年：2007
• 出版时间：November, 2007
• 年：2007
• 卷：16
• 期：11
• 页码：1907-1912
• 全文大小：600.6 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgical Orthopedics
  Neurosurgery
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0932

文摘

The aim of this study was to evaluate the diagnostic value of MRI and 18FDG-PET in bone marrow infiltration of the spine due to metastases of solid tumours and lymphoma in cancer patients. In 35 cancer patients (solid tumours n = 26, lymphoma n = 9) MRI of the spine and 18FDG-PET were reviewed and the detectability of metastases, infiltration of the spine, extent of disease, and therapeutic implications were compared. In 8/35 cases (23%) imaging technique showed concordantly no bone marrow infiltration. In 19/35 patients (54%), both MRI and 18FDG-PET revealed bone marrow infiltration of the axial skeleton. In 12/19 patients (63%), MRI showed more extensive disease which lead to subsequent therapy. The imaging findings of MRI and 18FDG-PET were discordant in 8/35 cases (23%). 18FDG-PET was false positive in two patients. In six patients, 18FDG-PET failed to detect bone metastases and bone marrow infiltration of the spine, which was detected by MRI and proven by clinical follow-up with subsequent therapy in two cases. MRI is more sensitive and specific than 18FDG-PET detecting bone marrow metastases and infiltration of the spine and has a great impact in staging cancer patients.