The flavivirus dengue induces hypertrophy of white matter astrocytes

详细信息    查看全文

• 作者：Kim M. Lee ; Kevin B. Chiu ; Hope A. Sansing ; Peter J. Didier…
• 关键词：Flavivirus ; Neuropathogenesis ; Astrocyte ; Glia ; Hypertrophy
• 刊名：Journal of NeuroVirology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：22
• 期：6
• 页码：831-839
• 全文大小：4283KB
• 刊物主题：Neurosciences; Virology; Infectious Diseases; Immunology; Neurology;
• 出版者：Springer International Publishing
• ISSN：1538-2443
• 卷排序：22

文摘

Flaviviruses, including Zika and dengue (DENV), pose a serious global threat to human health. Of the 50+ million humans infected with DENV annually, approximately 1–3 % progress to severe disease manifestations, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Several factors are suspected to mediate the course of infection and pathogenesis of DENV infection. DHF and DSS are associated with vascular leakage and neurological sequelae. Our hypothesis was that altered astrocyte activation and morphology would alter the dynamics of the extracellular space and hence, neuronal and vascular function. We investigated the mechanisms of neuropathogenesis DENV infection in rhesus macaques. There were decreased numbers of GFAP immunopositive astrocytes per unit area, although those that remained had increased arbor length and complexity. This was combined with structural hypertrophy of white matter astrocytes in the absence of increased vascular leakage. Combined, these studies show how even low-grade infection with DENV induces measurable changes within the parenchyma of infected individuals.