A novel model for evaluating thrombolytic therapy in dogs with ST-elevation myocardial infarction

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• 作者：Hong Zhang ; Yong-chun Cui ; Yi Tian ; Wei-min Yuan…
• 关键词：Thrombolytic therapy ; White thrombus ; Coronary artery occlusion
• 刊名：BMC Cardiovascular Disorders
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：598 KB
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• 作者单位：Hong Zhang (1)
  Yong-chun Cui (1)
  Yi Tian (1)
  Wei-min Yuan (1)
  Jian-zhong Yang (1)
  Peng Peng (1)
  Kai Li (1)
  Xiao-peng Liu (1)
  Dong Zhang (1)
  Ai-li Wu (1)
  Zhou Zhou (2)
  Yue Tang (1)
  
  1. Animal Experiment Center & Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Beijing, 100037, People’s Republic of China
  2. Center of Clinical Laboratory, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
  
• 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2261

文摘

Background There is still no standard large animal model for evaluating the effectiveness of potential thrombolytic therapies. Here, we aimed to develop a new beagle model with ST-elevation myocardial infarction (STEMI) by injecting autologous emboli with similar components of coronary thrombus.