Investigation of adverse effects of interactions between herbal drugs and natural blood clotting mechanism

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• 作者：M. S. Adhyapak ; M. S. Kachole
• 关键词：Medicinal plants ; Interaction ; Anticoagulant activity ; Clotting time
• 刊名：Journal of Thrombosis and Thrombolysis
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：41
• 期：4
• 页码：644-647
• 全文大小：334 KB
• 参考文献：1.Boon GD (1993) An overview of hemostasis. Toxic Pathol 21(2):170–179CrossRef
  2.Reutelingsperger CPM, Hornstra G, Hemker HC (1985) Isolation & partial purification of a novel anticoagulant from arteries of human umbilical cord. Eur J Biochem 151:625–629CrossRef PubMed
  3.Davie EW, Ranoff OD (1964) Waterfall sequence for intrinsic blood clotting. Science 145(3638):1310–1312CrossRef PubMed
  4.Stoukova SM, Thachuk VK (2002) Proteinases of the blood coagulation system and fibrinolysis as cell regulators. Biochem (Mosc) 67(1):1–2CrossRef
  5.Mann KG, Butenas S, Brummel K (2003) The dynamics of thrombin formation. Arterioscler, Thromb Vasc Biol 23:17CrossRef
  6.Narayanan S (1999) Multifunctional roles of thrombin. Ann Clin Lab Sci 29(4):275–280PubMed
  7.Kathiresan K, Ravindran VS, Muruganantham A (2006) Mangrove extracts prevent the blood coagulate. Ind J Biotech 5:252–254
  8.Ekanayake PM (2007) Isolation and purification of an anticoagulant from Schizymenia dubyi by fermentation. Food Sci Tech Int 13(5):355–359CrossRef
  9.Ganesh EA, Das S, Arun G, Balamurugan S, Raj RR (2009) Heparin like compound from green alga Chaetomorpha antennina—as potential anticoagulant. Asian J Med Sci 1(3):114–116
  10.Jesonbabu J, Spandana N, Reddy MS, Laxmi KA (2002) A bioactive compound from Piper betel with anticoagulant activity; Int. J Pharm Pharma Sci 4(Suppl 3):109–112
  11.Bungu L, Van der Venter M, Frost C (2008) Evidence for an in vitro anticoagulant and antithrombotic activity in Tubaghia violacea. Afr J Biotechnol 7(6):681–688
  12.Mahajan R, More D (2012) Evaluation of anticoagulant activity of aqueous and ethanolic extracts and their isolated phytochemicals of some medicinal plants. Int J Pharm Pharm Sci 4(Suppl 4):498–500
  13.Jain M, Yadav A, Tomar V, Kannojia P, Solanki SS, Tonpay SD (2009) Possible pharmacological basis for antithrombotic effect of Glycyrrhiza glabra in sprague dawley rats. Int J Pharm Sci Drug Res 1(2):113–115
  14.Francischetti IM, Monteiro RQ, Guimaraes JA (1997) Identification of glycyrrhizin as a thrombin inhibitor. Biochem Biophys Res Commun 235(1):259–263CrossRef PubMed
  15.Manicam C, Abdullah JO, Tohit ERM, Seman Z, Chin SC, Hamid M (2010) In vitro anticoagulant activities of Melastoma malabathricum Linn. Aqueous leaf extract: A preliminary novel finding. J Med Plants Res 4(14):1414–1472
  16.Shanmugam M, Mody KH, Oza RM, Ramavat BK (2001) Blood anticoagulant activity of a green marine alga Codium dwarkense (Codiaceae, Chlorophyta) in relation to its growth stages. Indian J Mar Sci 30:49–52
  17.Yoon SJ, Pereira MS, Pavao MS, Hwang JK, Pyun YR, Mourao PA (2002) The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin co-factor II. Thromb Res 106(1):51–58CrossRef PubMed
  18.Marzowk B, Haloui E, Akremi N, Aouni M, Marzouk Z, Fenina N (2012) Antimicrobial and anticoagulant activities of Citoullus colocynthis schrad leaves from Tunisia (Medenine). Afr J Pharm Pharm 6(26):1982–1988
  19.Rakhimov D, Malikova M, Vakhabov A, Abdura-Khimanov T, Ruziev O (1997) Plant polysaccharides IX Isolation and anticoagulant activity of the polysaccharides of Lagochilus usunachmaticus. Chem Nat Compd 33(5):534–535CrossRef
  20.Siritapetawee J, Thammasirirak S (2011) Purification and Characterization of a heteromultimeric glycoprotien from Artocarpus hetrophyllus latex with an inhibitory effect on human blood coagulation. Acta Biochem Pol 58(4):521–528
  21.Albuquerque RL, Queiroz KCS, Alves LG, Santos EA, Leite EL, Rocha HAO (2004) Heterofurans from Dictyota menstrualis have anticoagulant activity. Braz J Med Biol Res 37(2):167–171CrossRef PubMed
  22.Gadkari JV, Joshi VD (1991) Effect of ingestion of raw garlic on serum cholesterol level, clotting time and fibrinolytic activity in normal subjects. J Postgrad Med 37(3):128–131PubMed
  23.Tattelman E (2005) Health effects of garlic. Am Fam Physician 72(1):103–106PubMed
  24.Song CS, Sookion Y, Lee DJ, Nam CC (1963) A blood anticoagulant substance from garlic (Allium sativum). Yonsei Med J 4:21–26CrossRef PubMed
  25.Sa YS, Kim S-J, Choi H-S (2005) The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch. Pharm. Res. 28(6):667–674CrossRef PubMed
  26.Zeng F-Q, Xu H-x, Sim K-y, Gunsekera RM, Chen S-x (1998) The anticoagulant effects of Geum japonicum extract and its constituents. Phytother Res 12(2):146–148CrossRef
  27.Osoniyi O, Onajob F (2003) Coagulant and anticoagulant activities in Jatropha curcas latex. J Ethnopharmacol 89(1):101–105CrossRef PubMed
  28.Afonne OJ, Oriskwe OE, Obi E, Orish C, Akumka DD (2000) Some pharmacological properties of Synclisia scabrida III. Indian J Pharmacol 32:239–241
  29.Cai W, Xie L, Chen Y, Zang H (2013) Purification, characterization and anticoagulant activity of the polysaccharides from green tea. Carbohydr Polym 92(2):1086–1090CrossRef PubMed
  30.Sabnis M (2012) Viruddha Ahara: a critical view. A.Y.U. 33(3):332–336
  31.Dobson R (2001) Combining anticoagulant drugs with herbal medicine is risky, report says. B.M.J. 323:1270CrossRef
  32.Argento A, Tiraferri E, Marzaloni M (2000) Oral anticoagulants and medicinal plants. An emerging interaction. Ann Ital Med Int 15(2):139–143PubMed
  33.Myers SP (2002) Interactions between complementary medicines and warfarin. Aust Presc 25:54–56CrossRef
  34.Paoletti A, Gallo E, Beneme S, Vietri M, Lapi F, Volpi R, Menniti-Ippolito F, Gori L, Mugelli A, Firenzuoli F, Vannacci A (2011) Interactions between natural health products and oral anticoagulants: spontaneous reports in the Italian surveillance system of natural health products. Evid Based-Compliment Alternat Med, Vol. 2011, Article ID 612150
  35.Samuels N (2005) Herbal remedies and anticoagulant therapy. Thromb Haemost 93:3–7PubMed
  36.Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, Duan W, Koh HL, Zhou S (2005) Herb–drug interactions: a literature Review. Drugs 65(9):1239–1282CrossRef PubMed
  37.Tachijan A, Muria V, Jahangir A (2010) Use of herbal products and potential interactions in patients with cardiovascular diseases. J Am Coll Cardiol 55(6):515–525CrossRef
  38.Cupp MJ (1999) Herbal remedies: adverse effects and drug interactions. Am Fam Physician 59(5):1239–1244PubMed
  39.Heck AM, Dewitt BA, Lukes L (2000) Potential interactions between alternative therapies and warfarin. Am J Health-Syst Pharm 57(13):1221–1227PubMed
  40.Messina BA (2006) Herbal supplements: facts and myths-talking to your patients about herbal supplements. J Perianesth Nurs 21(4):268–278CrossRef PubMed
  41.Dapper DV, Achinike PW, Gwotmut MD (2007) The effects of Aloe vera [gel] on clotting time prothrombin time and Plasma Fibrinogen concentration in albino wistar rats. Port Harcourt J 2:56–60
  42.Ochei J, Kolhatkar A (2000) Medical laboratory science: theory and practice, 2nd edn. Mcgraw-Hill, New Delhi
  
• 作者单位：M. S. Adhyapak (1)
  M. S. Kachole (2)
  
  1. Department of Chemistry, Vivekanand College, Aurangabad, M.S., India
  2. Department of Biochemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Hematology
  
• 出版者：Springer Netherlands
• ISSN：1573-742X

文摘

Throughout the world, herbal medicines are consumed by most of the patients without considering their adverse effects. Many herbal medicines/plant extracts have been reported to interact with the natural blood clotting system. In continuation to this effort, thirty medicinal plant extracts were allowed to interact with citrated human blood and the clotting time was measured after re-calcification in vitro using Lee and White method. The aq. leaf ext. of Syzygium cumini and Camellia sinensis significantly prolonged the clotting time. In response to the prothrombin time and activated partial thromboplastin time tests, the ext. of C. sinensis showed normal APTT and marginally prolonged the PT to 16.7 s (control—15.2 s) while S. cumini showed normal PT but significantly prolonged the APTT to 66.9 s (control—20.7 s). This suggests that, C. sinensis acts on the extrinsic pathway while S. cumini on the intrinsic pathway. There are some common herbal formulations that are frequently used by the patients which contain above plant materials, like, Syzygium cumin in anti-diabetic formulations, while the ext. of C. sinensis is consumed frequently as beverage in many part of the world. Hence, patients having known bleeding tendency or haemophilia disease should take into account the interaction potential of these plants with the natural blood clotting system while taking herbal formulations containing above plants; specially, the patients suffering from intrinsic pathway factor deficiency should keep a limit on the consumption of S. cumini while extrinsic pathway factor deficiency patients should limit C. sinensis. Also, the medical practitioners should consider the patient’s food consumption history before doing any major surgical procedures.