CMTM1_v17 is associated with chemotherapy resistance and poor prognosis in non-small cell lung cancer

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• 作者：Jiahui Si ; Panpan Zhang ; Dan Tian ; Xing Wang…
• 关键词：Non ; small cell lung cancer ; Neoadjuvant chemotherapy ; CMTM1_v17 ; Chemoresistance ; Prognosis
• 刊名：World Journal of Surgical Oncology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：1176KB
• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819
• 卷排序：15

文摘

BackgroundConsidering neoadjuvant chemotherapy (NAC) prior to surgery could shrink and reduce the primary tumor and distant micro-metastases to reduce the high relapses rates, NAC has been an accepted therapeutic management for patients with non-small cell lung cancer (NSCLC). CMTM1_v17 is highly expressed in human testis tissues and solid tumor tissues but relatively low expression was obtained in the corresponding normal tissues. This study aims to investigate the significance of CMTM1_v17 in NSCLC and its association with platinum-based NAC efficacy.