pH-sensitive IPN hydrogel based on poly (aspartic acid) and poly (vinyl alcohol) for controlled release
详细信息 查看全文
- 作者：Miaomiao Liu (1)
Lilin Wang (1)
Haijia Su (1)
Hui Cao (1)
Tianwei Tan (1) - 关键词：Poly (aspartic acid) ; Interpenetrating polymer network ; Poly (vinyl alcohol) ; pH ; sensitive ; Drug delivery systems
- 刊名：Polymer Bulletin
- 出版年：2013
- 出版时间：October 2013
- 年：2013
- 卷：70
- 期：10
- 页码：2815-2827
- 全文大小：492KB
- 参考文献：1. Mehr MJZ, Pourjavadi A, Salimi H, Kurdtabar M (2009) Protein- and homo poly (amino acid)-based hydrogels with super-swelling properties. Polymer Adv Tech 20:655鈥?71 CrossRef
2. Ananta M, Brown RA, Mudera V (2012) A rapid fabricated living dermal equivalent for skin tissue engineering: an in vivo evaluation in an acute wound model. Tissue Eng Part A 18:352鈥?61 CrossRef
3. Singh B, Pal L (2011) Radiation crosslinking polymerization of sterculia polysaccharide鈥揚VA鈥揚VP for making hydrogel wound dressings. Int J Biol Macromol 48:501鈥?10 CrossRef
4. Ambrosio L, Santis RD, Nicolais L (1998) Composite hydrogels for implants. Proc IME H J Eng Med 212:93鈥?9 CrossRef
5. Delair T (2011) In situ forming polysaccharide-based 3D-hydrogels for cell delivery in regenerative medicine. Carbohydr Polymer 87:1013鈥?019 CrossRef
6. Li SF, Yang YJ, Li HB, Yang XL, Xu HB (2007) pH-responsive semi-interpenetrating networks hydrogels of poly(acrylic acid-acrylamide-methacrylate) and amylase. J Appl Polymer Sci 106:3792鈥?799 CrossRef
7. Han J, Wang K, Yang DZ, Nie J (2009) Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery. Int J Biol Macromol 44:229鈥?35 CrossRef
8. Lai FK, Li H (2011) Transient modeling of the reversible response of the hydrogel to the change in the ionic strength of solutions. Mech Mater 43:287鈥?98 CrossRef
9. Ali AE, AlArifi A (2009) Characterization and in vitro evaluation of starch based hydrogels as carriers for colon specific drug delivery systems. Carbohydr Polymer 78:725鈥?30 CrossRef
10. Rosalia R, Cammn AL, Angel C (2003) Cationic cellulose hydrogels: kinetics of the cross-linking process and characterization as pH/ion-sensitive drug delivery systems. J Contr Release 86:253 CrossRef
11. Li C, Luo GF, Wang HY (2011) Host-guest assembly of ph-responsive degradable microcapsules with controlled drug release behavior. J Phys Chem C 115:17651鈥?7659 CrossRef
12. Liu CH, Chen YQ, Chen JG (2010) Synthesis and characteristics of pH-sensitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly (aspartic acid) for in vitro drug delivery. Carbohydr Polymer 79:500鈥?06 CrossRef
13. Yang J, Wang F, Fang L, Tan TW (2006) Synthesis, characterization and application of a novel chemical sand-fixing agent-poly (aspartic acid) and its composites. Environ Pollut 149:125鈥?30 CrossRef
14. Young SJ, Jing L, Kim JH (2008) Dye adsorption characteristics of alginate/polyaspartate hydrogels. J Ind Eng Chem 14:726鈥?31 CrossRef
15. Yin LC, Ding JY, Zhang J, He CB, Tang C, Yin CH (2010) Polymer integrity related absorption mechanism of superporous hydrogel containing interpenetrating polymer networks for oral delivery of insulin. Biomaterials 31:3347鈥?356 CrossRef
16. Athawale WD, Kolekar SL, Raut SS (2003) Recent developments in polyurethanes and poly (acrylates) interpenetrating polymer networks. J Macromol Sci Polymer Rev 43:1鈥?6 CrossRef
17. Stauffer SR, Peppast NA (1992) Poly(vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing. Polymer 33:3932鈥?936 CrossRef
18. Wen X, Cao XL, Yin ZH, Wang T, Zhao CS (2009) Preparation and characterization of konjac glucomannan-poly (acrylic acid) IPN hydrogels for controlled release. Carbohydr Polymer 78:193鈥?98 CrossRef
19. Holloway JL, Lowman AM, Palmese GR (2010) Mechanical evaluation of poly (vinyl alcohol)-based fibrous composites as biomaterials for meniscal tissue replacement. Acta Biomater 6:4716鈥?724 CrossRef
20. Yang H, Horii F (2008) Investigation of the structure of poly (vinyl alcohol)-iodine complex hydrogels prepared from the concentrated polymer solutions. Polymer 49:785鈥?91 CrossRef
21. Ruiz J, Mantec贸n A, C谩diz V (2001) Synthesis and properties of hydrogels from poly (vinyl alcohol) and ethylenediaminetetraacetic dianhydride. Polymer 42:6347鈥?354 CrossRef
22. Kulkarni RV, Sreedhar V, Mutalik S, Shetty CM, Sa B (2010) Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin. Int. J. Biol. Macromol 47:520鈥?27 CrossRef
23. Wei L, Cai CH, Lin JP, Chen T (2009) Dual-drug delivery system based on hydrogel/micelle composites. Biomaterials 30:2606鈥?613 CrossRef
24. Liu MM, Su HJ, Tan TW (2012) Synthesis and properties of thermo- and pH-sensitive poly(N-isopropylacrylamide)/polyaspartic acid IPN hydrogels. Carbohydr Polym 87:2425鈥?431 CrossRef
25. Zhang XZ, Wu DQ, Chu CC (2004) Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials 25:3793鈥?805 CrossRef
26. Zhao Y, Kang J, Tan TW (2006) Salt-, pH- and temperature-responsive semi-interpenetrating polymer network hydrogel based on poly (aspartic acid) and poly (acrylic acid). Polymer 47:7702鈥?710 CrossRef
27. Tang QW, Sun XM, Li QH, Wu JH, Lin JM (2009) Fabrication of a high-strength hydrogel with an interpenetrating network structure. Colloid Surf Physicochem Eng Aspect 346:91鈥?8 CrossRef
28. Zhang JT, Bhat R, Jandt KD (2009) Temperature-sensitive PVA/PNIPAAm semi-IPN hydrogels with enhanced responsive properties. Acta Biomater 5:488鈥?97 CrossRef
29. Saini R, Bajpai AK (2005) Preparation and characterization of biocompatible spongy cryogels of poly (vinyl alcohol)-gelatin and study of water sorption behavior. Polymer Int 54:1233鈥?242 CrossRef
30. Yang XM, Zhu ZY, Liu Q, Chen XL, Ma MW (2008) Effects of PVA, agar contents, and irradiation doses on properties of PVA/ws-chitosan/glycerol hydrogels made by g-irradiation followed by freeze-thawing. Radiat Phys Chem 77:954鈥?60 CrossRef
31. Hua SB, Ma HZ, Li X, Yang HX, Wang AQ (2010) pH-sensitive sodium alginate/poly (vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol 46:517鈥?23 CrossRef
32. Wang Q, Zhang JP, Wang AQ (2009) Preparation and characterization of a novel pH-sensitive chitosan-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium. Carbohydr Polymer 78:731鈥?37 CrossRef
33. Mandal BB, Mann JK, Kundu SC (2009) Silk fibroin/gelatin multilayered films as a model system for controlled drug release. Eur J Pharm Sci 37:160鈥?71 CrossRef - 作者单位：Miaomiao Liu (1)
Lilin Wang (1)
Haijia Su (1)
Hui Cao (1)
Tianwei Tan (1)
1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China - ISSN：1436-2449
文摘
Various pH-sensitive sequential interpenetrating polymer network (IPN) hydrogels were prepared by introducing poly (vinyl alcohol) (PVA) hydrogel into Poly (aspartic acid) (PASP) hydrogel by freeze-thawing treatment to obtain a novel drug delivery system to the intestine. The structure and the morphologies of the prepared hydrogels were studied by Fourier Transform Infrared Spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal behavior and crystallinity of the hydrogels were characterized by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Their pH-sensitive properties moreover were studied and the results revealed that both PASP hydrogel and IPN hydrogels exhibited excellent pH-sensitivity. Furthermore, the controlled drug release properties of the hydrogels were also evaluated and results indicated that by increasing the PVA fraction in the IPN hydrogel, the release of Naproxen sodium was improved. These results show that the IPN hydrogels could be a suitable carrier for site-specific drug delivery in the intestine.