Esculin Inhibits the Inflammation of LPS-Induced Acute Lung Injury in Mice Via Regulation of TLR/NF-κB Pathways

详细信息    查看全文

• 作者：Zhang Tianzhu ; Wang Shumin
• 关键词：esculin ; lipopolysaccharide (LPS) ; lung injury ; TLR/NF ; κB pathway
• 刊名：Inflammation
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：38
• 期：4
• 页码：1529-1536
• 全文大小：4,501 KB
• 参考文献：1.Rubenfeld, G.D. 2003. Epidemiology of acute lung injury. Critical Care Medicine 31: S276–S284.PubMed View Article
  2.Zhang, X.M., K.J. Song, H.Z. Xiong, H.Y. Li, X. Chu, and X.M. Deng. 2009. Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice. International Immunopharmacology 9: 1525-529.PubMed View Article
  3.Matthay, M.A., G.A. Zimmerman, C. Esmon, J. Bhattacharya, B. Coller, C.M. Doerschuk, et al. 2003. Future research directions in acute lung injury summary of a national heart lung and blood institute working group. American Journal of Respiratory and Critical Care Medicine 167: 1027-035.PubMed View Article
  4.Chen, Z., X. Zhang, X. Chu, X. Zhang, K. Song, Y. Jiang, L. Yu, and X. Deng. 2010. Preventive effects of Valnemulin on lipopolysaccharide-induced acute lung injury in mice. Inflammation 33: 306-14.PubMed View Article
  5.Rubenfeld, G.D., E. Caldwell, E. Peabody, J. Weaver, D.P. Martin, M. Neff, et al. 2005. Incidence and outcomes of acute lung injury. The New England Journal of Medicine 353: 1685-693.PubMed View Article
  6.Pahl, H.L. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 6853-866.PubMed View Article
  7.Chen, Z., X. Zhang, X. Chu, X. Zhang, K. Song, Y. Jiang, L. Yu, and X. Deng. 2010. Preventive effects of valnemulin on lipopolysaccharideinduced acute lung injury in mice. Inflammation 33: 306-14.PubMed View Article
  8.Yang, R., L. Yang, X. Shen, W. Cheng, B. Zhao, K.H. Ali, Z. Qian, and H. Ji. 2012. Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice. European Journal of Pharmacology 674: 391-96.PubMed View Article
  9.Di, R., M.T. Huang, and C.T. Ho. 2011. Anti-inflammatory activities of mogrosides from Momordica grosvenoriin murine macrophages and a murine ear edema model. Journal of Agricultural and Food Chemistry 59: 7474-481.PubMed View Article
  10.Drexler, S.K., and B.M. Foxwell. 2010. The role of Toll-like receptors in chronic inflammation. International Journal of Biochemistry & Cell Biology 42: 506-18.View Article
  11.Lee, B.C., S.Y. Lee, H.J. Lee, G.S. Sim, J.H. Kim, J.H. Kim, Y.H. Cho, D.H. Lee, H.B. Pyo, T.B. Choe, D.C. Moon, Y.P. Yun, and J.T. Hong. 2007. Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis. Archives of Pharmacal Research 30: 1293-301.PubMed View Article
  12.Park, C., C.Y. Jin, G.Y. Kim, I.W. Choi, T.K. Kwon, B.T. Choi, S.J. Lee, W.H. Lee, and Y.H. Choi. 2008. Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. Toxicology and Applied Pharmacology 227: 219-28.PubMed View Article
  13.Kumazawa, Y., K. Kawaguchi, and H. Takimoto. 2006. Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha. Current Pharmaceutical Design 12: 4271-279.PubMed View Article
  14.Rubenfeld, G.D. 2003. Epidemiology of acute lung injury. Critical Care Medicine 31: 276-84.View Article
  15.Knapp, S., S. Florquin, D.T. Golenbock, and T. van der Poll. 2006. Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo. Journal of Immunology 176: 3189-195.View Article
  16.Chen, H., C. Bai, and X. Wang. 2010. The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine. Expert Review of Respiratory Medicine 4: 773-83.PubMed View Article
  17.Zhang, X.M., K.J. Song, H.Z. Xiong, H.Y. Li, X. Chu, and X.M. Deng. 2009. Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice. International Immunopharmacology 9: 1525-529.PubMed View Article
  18.Bhatia, M., and S. Moochhala. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. The Journal of Pathology 202: 145-56.PubMed View Article
  19.Minamino, T., and I. Komuro. 2006. Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. The Journal of Clinical Investigation 116: 2316-319.PubMed Central PubMed View Article
  20.Zhang, G., and S. Ghosh. 2001. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. Journal of Clinical Investigation 107: 13-9.PubMed Central PubMed View Article
  21.Akira, S., K. Takeda, and T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunology 2: 675-80.PubMed View Article
  22.Horng, T., G.M. Barton, R.A. Flavell, and R. Medzhitov. 2002. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420: 329-33.PubMed View Article
  23.Moine, P., R. McIntyre, M.D. Schwartz, et al. 2000. NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome. Shock 13: 85-1.PubMed View Article
  
• 作者单位：Zhang Tianzhu (1)
  Wang Shumin (1)
  
  1. Changchun University of Chinese Medicine, Changchun, 130117, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

In this study, we investigated anti-inflammatory effects of esculin (ESC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). ALI was induced in mice by intratracheal instillation of LPS, and ESC (20 and 40?mg/kg) was given orally 1?h prior to LPS administration. After 6?h, bronchoalveolar lavage fluid (BALF) and lung tissue were collected. ESC pretreatment decreased LPS-induced evident lung histopathological changes, lung wet-to-dry weight ratio, and lung myeloperoxidase activity. In addition, pretreatment with ESC inhibited inflammatory cells and proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β, and interleukin-6 in BALF. Furthermore, we demonstrated that ESC inhibited the Toll-like receptor-2 (TLR2), Toll-like receptor-4 (TLR4), myeloid differentiation primary response gene-88 (MyD88), and nuclear factor-κB (NF-κB) p65 in LPS-induced ALI. The results indicated that the ESC had a protective effect on LPS-induced ALI in mice.