Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis

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• 作者：Man-Bo Cai (1) (2)
  Xiao-Pai Wang (3)
  Jia-Xing Zhang (3)
  Hui-Qiong Han (1)
  Chao-Chun Liu (4)
  Jin-Xin Bei (1)
  Ruo-Jun Peng (1)
  Yi Liang (1)
  Qi-Sheng Feng (1)
  Hai-Yun Wang (3)
  Li-Zhen Chen (1)
  Sha Fu (3)
  Tiebang Kang (1)
  Jian-Yong Shao (1) (3)
  Yi-Xin Zeng (1)
  
• 关键词：Nasopharyngeal carcinoma ; Heat shock protein 70 ; Expression ; Prognosis
• 刊名：Journal of Translational Medicine
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：10
• 期：1
• 全文大小：617KB
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• 作者单位：Man-Bo Cai (1) (2)
  Xiao-Pai Wang (3)
  Jia-Xing Zhang (3)
  Hui-Qiong Han (1)
  Chao-Chun Liu (4)
  Jin-Xin Bei (1)
  Ruo-Jun Peng (1)
  Yi Liang (1)
  Qi-Sheng Feng (1)
  Hai-Yun Wang (3)
  Li-Zhen Chen (1)
  Sha Fu (3)
  Tiebang Kang (1)
  Jian-Yong Shao (1) (3)
  Yi-Xin Zeng (1)
  
  1. State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, 651# Dongfeng Road East, Guangzhou, 510060, China
  2. Cancer Research Institute, University of South China, Hengyang, China
  3. Department of Molecular Diagnostics, Cancer Center, Sun Yat-Sen University, 651# Dongfeng Road East, Guangzhou, 510060, China
  4. Wadsworth Center, New York State Department of Health, Albany, NY, USA
  

文摘

Background Heat shock protein 70, a stress protein, has been implicated in tumor progression. However, its role in nasopharyngeal carcinoma (NPC) progression has not yet been clearly investigated. Methods Immunohistochemistry (IHC) was employed to examine the expression patterns of Hsp70, human leukocyte antigen –A (HLA-A) in NPC tissue samples. Results The expression of Hsp70 exhibited different spatial patterns among nuclear, membrane and cytoplasm in 507 NPC tumor tissues. Kaplan-Meier survival analysis demonstrated that different Hsp70 expression patterns are correlated with different patient outcomes. High membranal and cytoplasmic levels of Hsp70 predicted good survival of patients. In contrast, high nuclear abundance of Hsp70 correlated with poor survival. Moreover, the membranal and cytoplasmic levels of Hsp70 were positively correlated with levels of the MHC I molecule HLA-A. Conclusions Different Hsp70 expression patterns had distinct predictive values. The different spatial abundance of Hsp70 may imply its important role in NPC development and provide insight for the development of novel therapeutic strategies involving immunotherapy for NPC.