Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma
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- 作者：Nan Ge (1) (2)
Huan-Xin Lin (1) (2)
Xiang-Sheng Xiao (1) (3)
Ling Guo (1) (4)
Hui-Min Xu (1) (2)
Xin Wang (1) (2)
Ting Jin (1) (2)
Xiu-Yu Cai (1) (2)
Yi Liang (1)
Wei-Han Hu (1) (2)
Tiebang Kang (1) - 刊名：Journal of Translational Medicine
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：8
- 期：1
- 全文大小：1309KB
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Huan-Xin Lin (1) (2)
Xiang-Sheng Xiao (1) (3)
Ling Guo (1) (4)
Hui-Min Xu (1) (2)
Xin Wang (1) (2)
Ting Jin (1) (2)
Xiu-Yu Cai (1) (2)
Yi Liang (1)
Wei-Han Hu (1) (2)
Tiebang Kang (1)
1. State Key Laboratory of Oncology in South China, Cancer Center of Sun Yat-Sen University, 510060, Guangzhou, China
2. Department of Radiation Oncology, Cancer Center of Sun Yat-Sen University, 510060, Guangzhou, China
3. Department of Breast Oncology, Cancer Center of Sun Yat-Sen University, 510060, Guangzhou, China
4. Department of Nasopharyngeal Carcinoma, Cancer Center of Sun Yat-Sen University, 510060, Guangzhou, China
文摘
Background Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with both the clinicopathological characteristics and prognoses of patients with hypopharyngeal squamous cell carcinoma. Method Tumor tissue samples from 85 patients with hypopharyngeal squamous cell carcinoma were collected, and the clinical follow-up data of these patients were recorded, and expression status of Oct4 and Sox2 were examined in these tissue samples by immunohistochemistry (IHC). Results Oct4 expression was found to be an independent predictive factor for overall survival (p = 0.004) in patients with hypopharyngeal squamous cell carcinoma and was independently related to loco-regional control (p = 0.001). Although Sox2 expression status showed no significant association with overall survival (p = 0.166), disease-free survival (p = 0.680) or loco-regional control (p = 0.383), when using a subgroup analysis, the subgroup with both high Oct4 and Sox2 expression had the best prognosis (p = 0.000). Sox2 expression could be a potential prognostic predictor for patients with hypopharyngeal squamous cell carcinoma. Simultaneous analyses of Oct4 and Sox2 expression could be more effective in evaluating the prognoses of patients with hypopharyngeal squamous cell carcinoma. Conclusion Oct4 expression is an independent predictive factor for patients with hypopharyngeal squamous cell carcinoma, suggesting that Oct4 expression may be a useful indicator for predicting the prognosis of hypopharyngeal squamous cell carcinoma.