A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice

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• 作者：Wesley M. Raup-Konsavage ; Timothy K. Cooper…
• 关键词：Ulcerative colitis ; MYC ; Glycogen synthase kinase ; Lithium ; Colonic regeneration
• 刊名：Digestive Diseases and Sciences
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：61
• 期：2
• 页码：410-422
• 全文大小：4,369 KB
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• 作者单位：Wesley M. Raup-Konsavage (1)
  Timothy K. Cooper (2) (3)
  Gregory S. Yochum (1)
  
  1. Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, 500 University Dr., H171, Hershey, PA, 17033, USA
  2. Department of Comparative Medicine, The Pennsylvania State University College of Medicine, 500 University Dr., H171, Hershey, PA, 17033, USA
  3. Department of Pathology, The Pennsylvania State University College of Medicine, 500 University Dr., H054, Hershey, PA, 17033, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gastroenterology
  Hepatology
  Oncology
  Transplant Surgery
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-2568

文摘

Background Chronic inflammation disrupts the colonic epithelial layer in patients afflicted by ulcerative colitis (UC). The use of inhibitors of glycogen synthase kinase three beta (GSK3β) has proven efficacious to mitigate disease symptoms in rodent models of UC by reducing the pro-inflammatory response. Less is known about whether these inhibitors promote colonic regeneration by stimulating proliferation of colonic epithelial cells.