Pulsed Radiofrequency Treatment Enhances Dorsal Root Ganglion Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a Rat Model of Neuropathic Pain

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• 作者：Yiming Liu ; Yi Feng ; Tingjie Zhang
• 关键词：Hyperpolarization ; activated cyclic nucleotide ; gated channel ; Pulsed radiofrequency ; Neuropathic pain ; Chronic constriction injury ; Neuromodulation
• 刊名：Journal of Molecular Neuroscience
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：57
• 期：1
• 页码：97-105
• 全文大小：628 KB
• 参考文献：Aksu R, Ugur F, Bicer C et al (2010) The efficiency of pulsed radiofrequency application on L5 and l6 dorsal roots in rabbits developing neuropathic pain. Reg Anesth Pain Med 35(1):11-5CrossRef PubMed
  Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33(1):87-07CrossRef PubMed
  Biel M, Wahl-Schott C, Michalakis S, Zong X (2009) Hyperpolarization-activated cation channels: from genes to function. Physiol Rev 89(3):847-85CrossRef PubMed
  Chaplan SR, Guo HQ, Lee DH et al (2003) Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci 23(4):1169-178PubMed
  Chung JM, Chung K (2002) Importance of hyperexcitability of DRG neurons in neuropathic pain. Pain Pract 2(2):87-7CrossRef PubMed
  Cohen SP, Sireci A, Wu CL, Larkin TM, Williams KA, Hurley RW (2006) Pulsed radiofrequency of the dorsal root ganglia is superior to pharmacotherapy or pulsed radiofrequency of the intercostal nerves in the treatment of chronic postsurgical thoracic pain. Pain Physician 9(3):227-35PubMed
  Dalle C, Eisenach JC (2005) Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain. Reg Anesth Pain Med 30(3):243-48CrossRef PubMed
  Du L, Wang SJ, Cui J, He WJ, Ruan HZ (2013a) Inhibition of HCN channels within the periaqueductal gray attenuates neuropathic pain in rats. Behav Neurosci 127(2):325-29CrossRef PubMed
  Du L, Wang SJ, Cui J, He WJ, Ruan HZ (2013b) The role of HCN channels within the periaqueductal gray in neuropathic pain. Brain Res 150036-44
  Emery EC, Young GT, Berrocoso EM, Chen L, McNaughton PA (2011) HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science 333(6048):1462-466CrossRef PubMed
  Emery EC, Young GT, McNaughton PA (2012) HCN2 ion channels: an emerging role as the pacemakers of pain. Trends Pharmacol Sci 33(8):456-63CrossRef PubMed
  Flatters SJ, Bennett GJ (2004) Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain 109(1-2):150-61CrossRef PubMed
  Hagiwara S, Iwasaka H, Takeshima N, Noguchi T (2009) Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: Roles of descending adrenergic and serotonergic systems. Eur J Pain 13(3):249-52CrossRef PubMed
  Hains BC, Saab CY, Klein JP, Craner MJ, Waxman SG (2004) Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neurosci 24(20):4832-839CrossRef PubMed
  Hamann W, Abou-Sherif S, Thompson S, Hall S (2006) Pulsed radiofrequency applied to dorsal root ganglia causes a selective increase in ATF3 in small neurons. Eur J Pain 10(2):171-76CrossRef PubMed
  Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32(1):77-8CrossRef PubMed
  Hatch RJ, Jennings EA, Ivanusic JJ (2013) Peripheral hyperpolarization-activated cyclic nucleotide-gated channels contribute to inflammation-induced hypersensitivity of the rat temporomandibular joint. Eur J Pain 17(7):972-82CrossRef PubMed
  He C, Chen F, Li B, Hu Z (2014) Neurophysiology of HCN channels: from cellular functions to multiple regulations. Prog Neurobiol 1121-23
  Jiang YQ, Xing GG, Wang SL et al (2008) Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain 137(3):495-06CrossRef PubMed
  Ke M, Yinghui F, Yi J et al (2013) Efficacy of pulsed radiofrequency in the treatment of thoracic postherpetic neuralgia from the angulus costae: a randomized, double-blinded, controlled trial. Pain Physician 16(1):15-5PubMed
  Kerstman E, Ahn S, Battu S, Tariq S, Grabois M (2013) Neuropathic pain. Handb Clin Neurol 110175-187
  Li CY, Song YH, Higuera ES, Luo ZD (2004) Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. J Neurosci 24(39):8494-499PubMed Central CrossRef PubMed
  Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature 393(6685):587-91CrossRef PubMed
  Mazo I, Rivera-Arconada I, Roza C (2013) Axotomy-induced changes in activity-dependent slowing in peripheral nerve fibres: Role of hyperpolarization-activated/HCN channel current. Eur J Pain 17(9):1281-290CrossRef PubMed
  Moosmang S, Stieber J, Zong X, Biel M, Hofmann F, Ludwig A (2001) Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem 268(6):1646-652CrossRef PubMed
  Park HW, Ahn SH, Son JY et al (2012) Pulsed radiofrequency application reduced mechanical h
• 作者单位：Yiming Liu (1)
  Yi Feng (1)
  Tingjie Zhang (1)
  
  1. Pain medicine department, Peking University People’s Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing, 100044, China
  
• 刊物主题：Neurosciences; Neurochemistry; Cell Biology; Proteomics; Neurology;
• 出版者：Springer US
• ISSN：1559-1166

文摘

Pulsed radiofrequency (PRF) treatment is a minimally invasive technique with multiple therapeutic applications. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel mediating Ih may regulate neuropathic pain signaling. This study aimed to determine whether PRF suppresses neuropathic pain by altering HCN channel expression in dorsal root ganglion (DRG) neurons. Male Sprague Dawley rats with sciatic nerve chronic constriction injury (CCI) were randomly assigned to PRF (n--0) and sham control (n--0) groups, respectively. On postoperative day 7 (D07), PRF or sham treatment was delivered to the proximal sciatic nerve for 8 min. Behavioral tests were performed before surgery (D0), on D07, and on D1, D7, and D14 after PRF or sham treatment. HCN1 and HCN2 expression levels in the DRG were examined by immunohistochemistry and Western blot. The results showed that thermal hyperalgesia, mechano-allodynia, and mechano-hyperalgesia were lower, and DRG expression levels of HCN1 and HCN2 higher, in the PRF group compared with sham control animals (all P-lt;-.05 at D14). In conclusion, PRF can upregulate HCN channel expression in the DRG of rats with sciatic nerve CCI. How this regulation of Ih in nociceptive afferents contributes to the suppression of neuropathic pain by PRF remains to be determined. Keywords Hyperpolarization-activated cyclic nucleotide-gated channel Pulsed radiofrequency Neuropathic pain Chronic constriction injury Neuromodulation