Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway
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- 作者：Yingxia Lan ; Yi Zou ; Tingting Huang ; Xiaozheng Wang…
- 关键词：biosynthesis ; maremycin ; N ; methylation ; methyltransferase ; epimerization
- 刊名：SCIENCE CHINA Chemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：59
- 期：9
- 页码：1224-1228
- 全文大小：1,519 KB
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Chinese Library of Science
Chemistry - 出版者：Science China Press, co-published with Springer
- ISSN：1869-1870
- 卷排序：59
文摘
The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling with knockout mutant strains led to the identification of new products correlated to the maremycin biosynthesis, in particular the “demethyl”-maremycins with an unexpected D-tryptophan unit. A biosynthetic pathway for the maremycins is proposed and plausible reasoning for tryptophan epimerization in the demethylmaremycin biosynthesis is also provided.