Autoimmunity as a possible cause of growth hormone deficiency

详细信息    查看全文

• 作者：A. De Bellis MD ; A. Colao ; G. Tirelli…
• 关键词：Antipituitary antibodies ; autoimmune hypophysitis ; idiopathic GH deficiency
• 刊名：Journal of Endocrinological Investigation
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：31
• 期：12
• 页码：1132-1134
• 全文大小：
• 参考文献：1.S枚nksen PH. Replacement therapy in hypothalamo-pituitary insufficiency after childhood: management in the adult. Horm Res 1990, 33 (Suppl 4): 43鈥?1.CrossRef
  2.de Boer H, Blok GJ, Van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995, 16: 63鈥?6.PubMed CrossRef
  3.Littley MD, Shalet SM, Beardwell CG, et al. Hypopituitarism following external radiotherapy for pituitary tumors in adults. Q J Med 1989, 70: 145鈥?0.PubMed
  4.Aimaretti G, Ambrosio MR, Di Somma C, et al. Residual pituitary function after brain injury induced hypopituitarism: a prospective 12-month study. J Clin Endocrinol Metab 2005, 90: 6085鈥?2.PubMed CrossRef
  5.Tanriverdi F, Senyurek H, Unluhizarci K, Selcuklu A, Casanueva FF, Kelestimur F. High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma. J Clin Endocrinol Metab 2006, 91: 2105鈥?1.PubMed CrossRef
  6.Wagner JK, Eble A, Hindmarsh PC, Mullis PE. Prevalence of human GH-1 gene alterations in patients with isolated growth hormone deficiency. Pediatr Res 1998, 43: 105鈥?0.PubMed
  7.Salvatori R, Fan X, Phillips JA 3rd, et al. Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib. J Clin Endocrinol Metab 2001, 86: 273鈥?.PubMed
  8.Goudie RB, Pinkerton PH. Anterior hypophysitis and Hashimoto鈥檚 disease in a young woman. J Pathol Bacteriol 1962, 83: 584鈥?.PubMed CrossRef
  9.Jenkins PJ, Chew SL, Lowe DG,et al. Lymphocytic hypophysitis: unusual features of a rare disorder. Clin Endocrinol 1995, 42: 529鈥?4.CrossRef
  10.Sato N, Sze G, Endo K. Hypophysitis: endocrinologic and dynamic MR findings. Am J Neuroradiol 1998, 19: 439鈥?4.PubMed
  11.De Bellis A, Bizzarro A, Bellastella A. Pituitary antibodies and lymphocytic hypophysitis. Best Pract Res Clin Endocrinol Metab 2005, 19: 67鈥?4.PubMed CrossRef
  12.Burke CW, Moore RA, Rees LH, Bottazzo GF, Mashiter K, Bitensky L. Isolated ACTH deficiency and TSH deficiency in the adult. J R Soc Med 1979, 72: 328鈥?5.PubMed Central PubMed
  13.Barkan AL, Kelch RP, Marshall JC. Isolated gonadotrope failure in the polyglandular autoimmune syndrome. N Engl J Med 1985, 312: 1535鈥?0.PubMed CrossRef
  14.Caturegli P, Newschaffer C, Olivi A, Pomper MG, Burger PC, Rose NR. Autoimmune hypophysitis. Endocr Rev 2005, 26: 599鈥?14.PubMed CrossRef
  15.Bellastellaai A, Bizzarroai A, Coronella C, Bellastellaai G, Sinisiai AA, De Bellisai A. Lymphocytic hypophysitis: a rare or underestimated disease? Eur J Endocrinol 2003, 149: 363鈥?6.CrossRef
  16.De Bellis A, Colao A, Di Salle F, et al. A longitudinal study of vasopressin cell antibodies, posterior pituitary function, and magnetic resonance imaging evaluations in subclinical autoimmune central diabetes insipidus. J Clin Endocrinol Metab 1999, 84: 3047鈥?1.PubMed CrossRef
  17.Crock PA. Cytosolic autoantigens in lymphocytic hypophysitis. J Clin Endocrinol Metab 1998, 83: 609鈥?8.PubMed
  18.Bensing S, Kasperlik-Zaluska AA, Czarnocka B, Crock PA, Hulting A. Autoantibodies against pituitary proteins in patients with adrenocorticotropin-deficiency. Eur J Clin Invest 2005, 35: 126鈥?2.PubMed CrossRef
  19.O鈥檇wyer DT, Smith AI, Matthew ML, et al. Identification of the 49-kDa auoantigen associated with lymphocytic hypophysitis as alpha-enolase. J Clin Endocrinol Metab 2002, 87: 752鈥?.PubMed
  20.Nishiki M, Murakami Y, Ozawa Y, Kato Y. Serum antibodies to human pituitary membrane antigens in patients with autoimmune lymphocytic hypophysitis and infundibuloneurohypophysitis. Clin Endocrinol (Oxf) 2001, 54: 327鈥?3.CrossRef
  21.Tanaka S, Tatsumi KI, Takano T, Murakami Y, Takao T, Hashimoto K. Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis. Eur J Endocrinol 2002, 147: 767鈥?5.PubMed CrossRef
  22.Beressi N, Beressi JP, Cohen R, Modigliani E. Lymphocytic hypophysitis. A review of 145 cases. Ann Intern Med 1999, 150: 327鈥?1.
  23.Bottazzo GF, Mclntosh C, Stanford W, Preece M. Growth hormone cell antibodies and partial growth hormone deficiency in a girl with Turner鈥檚 syndrome. Clin Endocrinol 1980, 12: 1鈥?.CrossRef
  24.De Bellis A, Bizzarro A, Conte M, et al. Antipituitary antibodies in adults with apparently idiopathic growth hormone deficiency and in adults with autoimmune endocrine diseases. J Clin Endocrinol Metab 2003, 88: 650鈥?.PubMed CrossRef
  25.De Bellis A, Bizzarro A, Perrino S, et al. Characterization of antipituitary antibodies targeting pituitary hormone-secreting cells in idiopathic growth hormone deficiency and autoimmune endocrine disease. Clin Endocrinol 2005, 63: 45鈥?.CrossRef
  26.De Bellis A, Salerno M, Conte M, et al. Antipituitary antibodies recognized GH-producing cells in children with idiopathic growth hormone deficiency and in children with idiopathic short stature. J Clin Endocrinol Metab 2006, 91: 2484鈥?.PubMed CrossRef
  27.Iughetti L, De Bellis A, Predieri B, et al. Growth hormone impaired secretion and antipituitary antibodies in patients with coeliac disease and poor catch-up growth after a long gluten-free diet period: a causal association? Eur J Pediatr 2006, 165: 897鈥?03.PubMed CrossRef
  28.Manetti L, Lupi I, Morselli L, et al. Prevalence and functional significance of antipituitary antibodies in patients with autoimmune and non-autoimmune thyroid diseases. J Clin Endocrinol Metab 2007, 92: 2176鈥?1.PubMed CrossRef
  
• 作者单位：A. De Bellis MD (1)
  A. Colao (2)
  G. Tirelli (1)
  G. Ruocco (1)
  C. Di Somma (2)
  M. Battaglia (1)
  E. Pane (1)
  G. Bellastella (1)
  A. Dello lacovo (1)
  A. A. Sinisi (1)
  A. Bizzarro (1)
  A. Bellastella (1)
  
  1. Department of Clinical and Experimental Medicine and Surgery 鈥淔. Magrassi, A. Lanzara鈥? Second University of Naples, Via Pansini 5, 80131, Napoli, Italy
  2. Department of Molecular and Clinical Endocrinology and Oncology. 鈥淔ederico II鈥? University of Naples, Naples, Italy
  
• 刊物类别：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 刊物主题：Medicine/Public Health, general; Endocrinology; Metabolic Diseases;
• 出版者：Springer International Publishing
• ISSN：1720-8386

文摘

A possible autoimmune aggression to pituitary somatotrophs has been suggested by the occurrence of antipituitary antibodies (APA) directed against GH-secreting cells in some cases of GH deficiency (GHD) both in adults and in children and in some patients with autoimmune poliendocrine syndrome. We also detected APA in some patients with idiopathic short stature (ISS) and suggested that the presence of these antibodies could identify those of them prone to develop GHD. In fact, patients with ISS, resulted positive for APA at the first observation, during a longitudinal follow-up showed an impaired GH response to the stimuli in subsequent years suggestive of acquired GHD. Also in such patients we demonstrated that the target of APA were the somatotrophs and that an autoimmune attack to these cells may be the underlying cause of hormonal impairment in several children with GHD positive for APA. In this connection we suggested that in these patients an early iso-hormonal therapy with recombinant GH may be useful to interrupt or delay the progression towards a clinical GHD. Keywords Antipituitary antibodies autoimmune hypophysitis idiopathic GH deficiency