Synthesis and antimicrobial activity of 3-aroyl-4-heteroaryl pyrroles and pyrazoles

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• 作者：Shaik Sharafuddin Basha (1)
  Putta Ramachandra Reddy (1)
  Adivireddy Padmaja (1)
  Venkatapuram Padmavathi (1)
  Kalla Chandra Mouli (2)
  Tartte Vijaya (2)
  
  1. Department of Chemistry ; Sri Venkateswara University ; Tirupati ; 517 502 ; Andhra Pradesh ; India
  2. Department of Botany ; Sri Venkateswara University ; Tirupati ; 517 502 ; Andhra Pradesh ; India
  
• 关键词：Thiazoles ; Pyrazoles ; Pyrroles ; 1 ; 3 ; Dipolar cycloaddition ; Antimicrobial activity
• 刊名：Medicinal Chemistry Research
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：24
• 期：3
• 页码：954-964
• 全文大小：539 KB
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• 刊物主题：Pharmacology/Toxicology; Biochemistry, general; Cell Biology;
• 出版者：Springer US
• ISSN：1554-8120

文摘

A variety of bis heterocycles-heteroaryl pyrazoles (5) and pyrroles (6) were prepared from heteroaryl chalcones adopting 1,3-dipolar cycloaddition reaction and studied their antimicrobial activity. The compounds 5d and 5f having bromo and nitro substituents on the aromatic ring are the potent antimicrobial agents against Bacillus subtilis and Aspergillus niger.