Fluorescence Titrations of Bio-relevant Complexes with DNA: Synthesis, Structural Investigation, DNA Binding/Cleavage, Antimicrobial and Molecular Docking Studies

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• 作者：Thesingu Rajan Arun ; Ramasamy Subramanian ; Seemon Packianathan…
• 关键词：Schiff base ; DNA binding ; Fluorescence ; DNA cleavage ; Anti ; pathogenic ; Molecular docking
• 刊名：Journal of Fluorescence
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：25
• 期：4
• 页码：1127-1140
• 全文大小：4,137 KB
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• 作者单位：Thesingu Rajan Arun (1)
  Ramasamy Subramanian (2)
  Seemon Packianathan (1)
  Natarajan Raman (1)
  
  1. Research Department of Chemistry, VHNSN College, Virudhunagar, Tamilnadu, 626 001, India
  2. Centre for Scientific and Applied Research, PSN College of Engineering and Technology, Tirunelveli, Tamilnadu, 627152, India
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biophysics and Biomedical Physics
  Biotechnology
  Biochemistry
  Analytical Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4994

文摘

In the present work, we attempted to develop new metal complexes (Cu(II), Co(II), Ni(II) and Zn(II)) of the imine ligand which was synthesized from 9,10-phenanthrenequinone and para-anisidine. With an intention to make the complexes most stable, very special chelating amino acid has been coordinated to the metal centre. The resultant metal complexes have been characterized by variety of techniques including FT-IR, UV–Vis., 1H NMR, 13C NMR, powder XRD, EPR and mass spectral studies. The interaction of the complexes with DNA has been effectively examined and explored by fluorescence titration, UV–Vis absorption, viscometer titration, cyclic voltammetry (CV) and differential pulse voltammetry. Moreover, molecular docking analysis has been performed to understand the nature of binding of the complexes with DNA. These studies prove that CT DNA interaction of the complexes follows intercalation mode. The metal complexes exhibit effective cleavage of pUC19 DNA by an oxidative cleavage mechanism. The antimicrobial screening indicates that these complexes are good antimicrobial agents against various organisms.