Molecular Characterization of Virulent Newcastle Disease Virus Isolates from Chickens during the 1998 NDV Outbreak in Kazakhstan
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- 作者：Andrey Bogoyavlenskiy ; Vladimir Berezin ; Alexey Prilipov ; Eugeniy Usachev ; Olga Lyapina ; Svetlana Levandovskaya ; Ilya Korotetskiy ; Valentina Tolmacheva ; Nailya Makhmudova and Svetlana Khudyakova ; et al.
- 关键词：chicken ; fusion gene ; Newcastle disease virus ; phylogenetic characterization ; virulent
- 刊名：Virus Genes
- 出版年：2005
- 出版时间：August 2005
- 年：2005
- 卷：31
- 期：1
- 页码：13-20
- 全文大小：268 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Medical Microbiology
Virology
Plant Sciences - 出版者：Springer Netherlands
- ISSN：1572-994X
文摘
Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world and has the possibility to cause outbreaks in chicken flocks in future. To assess the evolutionary characteristics of 10 NDV strains isolated from chickens in Kazakhstan during 1998 we investigated the phylogenetic relationships among these viruses and viruses described previously. For genotyping, fusion (F) gene phylogenetic analysis (nucleotide number 47-421) was performed using sequences of Kazakhstanian isolates as compared to sequences of selected NDV strains from GenBank. Phylogenetic analysis showed that all newly characterized strains belonged to the genetic group designated as VIIb. All strains possessed a virulent fusion cleavage site (RRQRR/F) belonging to velogenic or mesogenic pathotypes with intracerebral pathogenicity indexes (ICPI) varying from 1.05 to 1.87.