Risk factors for hypernatremia in patients with short- and long-term tolvaptan treatment

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• 作者：Keita Hirai ; Tatsuki Shimomura…
• 关键词：Hypernatremia ; Tolvaptan ; Diuretics ; Heart failure ; Liver cirrhosis
• 刊名：European Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：72
• 期：10
• 页码：1177-1183
• 全文大小：290 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1041
• 卷排序：72

文摘

PurposeThe long-term efficacy of tolvaptan, a vasopressin V2 receptor antagonist, has been reported. However, the safety of long-term treatment remains to be fully elucidated. We assessed the safety profile of tolvaptan with respect to hypernatremia.