The association with Turner syndrome significantly affects the course of Hashimoto’s thyroiditis in children, irrespective of karyotype

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• 作者：Tommaso Aversa ; Maria Francesca Messina ; Laura Mazzanti ; Mariacarolina Salerno…
• 关键词：Chromosomopathies ; Hyperthyroidism ; Overt hypothyroidism ; Subclinical hypothyroidism ; Thyroid autoimmune disease ; Thyroid function patterns
• 刊名：Endocrine
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：50
• 期：3
• 页码：777-782
• 全文大小：375 KB
• 参考文献：1.A. Lleo, L. Moroni, L. Caliari, P. Invernizzi, Autoimmunity and Turner’s syndrome. Autoimmun. Rev. 11, A538–A543 (2012)CrossRef PubMed
  2.V.K. Bakalov, C. Cheng, J. Zhou, C.A. Bondy, X-chromosome gene dosage and the risk of diabetes in Turner syndrome. J. Clin. Endocrinol. Metab. 94, 3289-296 (2009)PubMedCentral CrossRef PubMed
  3.S. Livadas, P. Xekouki, F. Fouka, C. Kanaka-Gantenbein, I. Kaloumenou, A. Mavrou, N. Constantinidou, C. Dacou-Voutetakis, Prevalence of thyroid dysfunction in Turner’s syndrome: a long-term follow-up study and brief literature review. Thyroid 15, 1061-066 (2005)CrossRef PubMed
  4.I. Fukuda, N. Hizuka, M. Kurimoto, J. Morita, S. Tanaka, Y. Yamakado, K. Takano, Autoimmune thyroid diseases in 65 Japanese women with Turner syndrome. Endocr. J. 56, 983-86 (2009)CrossRef PubMed
  5.D. Larizza, V. Calcaterra, M. Martinetti, Autoimmune stigmata in Turner syndrome: when lacks an X chromosome. J. Autoimmun. 33, 25-0 (2009)CrossRef PubMed
  6.A. Grossi, A. Crinò, R. Luciano, A. Lombardo, M. Cappa, A. Fierabracci, Endocrine autoimmunity in Turner syndrome. Ital. J. Pediatr. 39, 79 (2013)PubMedCentral CrossRef PubMed
  7.K.T. J?rgensen, K. Rostgaard, I. Bache, R.J. Biggar, N.M. Nielsen, N. Tommerup, M. Frisch, Autoimmune diseases in women with Turner’s syndrome. Arthritis Rheum. 62, 658-66 (2010)CrossRef PubMed
  8.L. Chiovato, D. Larizza, G. Bendinelli, M. Tonacchera, M. Marinó, C. Mammoli, R. Lorini, F. Severi, A. Pinchera, Autoimmune hypothyroidism and hyperthyroidism in patients with Turner’s syndrome. Eur. J. Endocrinol. 134, 568-75 (1996)CrossRef PubMed
  9.G. Radetti, L. Mazzanti, C. Paganini, S. Bernasconi, G. Russo, F. Rigon, E. Cacciari, Frequency, clinical and laboratory features of thyroiditis in girls with Turner’s syndrome. The Italian Study Group for Turner’s Syndrome. Acta Paediatr. 84, 909-12 (1995)CrossRef PubMed
  10.M. Elsheikh, J.A. Wass, G.S. Conway, Autoimmune thyroid syndrome in women with Turner’s syndrome—the association with karyotype. Clin. Endocrinol. 55, 223-26 (2001)CrossRef
  11.A. Gawlik, T. Gawlik, A. Januszek-Trzciakowska, H. Patel, E. Malecka-Tendera, Incidence and dynamics of thyroid dysfunction and thyroid autoimmunity in girls with Turner’s syndrome: a long-term follow-up study. Horm. Res. Paediatr. 76, 314-20 (2011)CrossRef PubMed
  12.M. Wasniewska, A. Corrias, M.F. Messina, G. Crisafulli, G. Salzano, M. Valenzise, A. Mussa, F. De Luca, Graves-disease prevalence in a young population with Turner syndrome. J. Endocrinol. Invest. 33, 69-0 (2010)CrossRef PubMed
  13.M. Valenzise, T. Aversa, A. Corrias, L. Mazzanti, M. Cappa, G. Ubertini, E. Scarano, A. Mussa, M.F. Messina, F. De Luca, M. Wasniewska, Epidemiology, presentation and long-term evolution of Graves-disease in children, adolescents and young adults with Turner syndrome. Horm. Res. Paediatr. 81, 245-50 (2014)PubMed
  14.M. Wasniewska, A. Corrias, M. Salerno, A. Mussa, D. Capalbo, M.F. Messina, T. Aversa, S. Bombaci, F. De Luca, M. Valenzise, Thyroid function patterns at Hashimoto’s thyroiditis presentation in childhood and adolescence are mainly conditioned by patients-age. Horm. Res. Paediatr. 78, 232-36 (2012)CrossRef PubMed
  15.M. Niedziela, Subclinical hypothyroidism: dilemmas in the treatment of children. J. Endocrinol. Invest. 30, 529-31 (2007)CrossRef PubMed
  16.M. Wasniewska, M. Salerno, A. Cassio, A. Corrias, T. Aversa, G. Zirilli, D. Capalbo, M. Bal, A. Mussa, F. De Luca, Prospective evaluation of the natural course of idiopathic subclinical hypothyroidism in childhood and adolescence. Eur. J. Endocrinol. 160, 417-21 (2009)CrossRef PubMed
  17.F. De Luca, M. Wasniewska, G. Zirilli, T. Aversa, T. Arrigo, At the end of a two-year follow-up elevated TSH levels normalize or remain unchanged in most the children with subclinical hypothyroidism. Ital. J. Pediatr. 36, 11 (2010)PubMedCentral CrossRef PubMed
  18.M. Cerbone, C. Bravaccio, D. Capalbo, M. Polizzi, M. Wasniewska, D. Cioffi, N. Improda, M. Valenzise, D. Bruzzese, F. De Luca, M. Salerno, Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism. Eur. J. Endocrinol. 164, 591-97 (2011)CrossRef PubMed
  19.M. Wasniewska, A. Corrias, T. Aversa, M. Valenzise, A. Mussa, L. De Martino, F. Lombardo, F. De Luca, M. Salerno, Comparative evaluation of therapy with L-thyroxine versus no treatment in children with idiopathic and mild subclinical hypothyroidism. Horm. Res. Paediatr. 77, 376-81 (2012)CrossRef PubMed
  20.F. De Luca, D. Corica, E. Pitrolo, S. Santucci, M. Romeo, Idiopathic and mild subclinical hypothyroidism in childhood: clinical management. Minerva Pediatr. 66, 63-8 (2014)PubMed
  21.A. Monzani, F. Prodam, A. Rapa, S. Moia, V. Agarla, S. Bellone, G. Bona, Endocrine disorders in childhood and adolescence. Natural history of subclinical hypothyroidism in children and adolescents and potential effects of replacement therapy
• 作者单位：Tommaso Aversa (1)
  Maria Francesca Messina (1)
  Laura Mazzanti (2)
  Mariacarolina Salerno (3)
  Alessandro Mussa (4)
  Maria Felicia Faienza (5)
  Emanuela Scarano (2)
  Filippo De Luca (1)
  Malgorzata Wasniewska (1)
  
  1. Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy
  2. Department of Pediatrics, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy
  3. Pediatric Endocrinology Unit, Department of Translational Medical Sciences, University “Federico II-of Naples, Naples, Italy
  4. Department of Pediatrics, University of Turin, Turin, Italy
  5. Pediatrics Unit, Department of Biomedical Sciences and Human Oncology, University of Bari ‘A. Moro- Bari, Italy
  
• 刊物主题：Endocrinology; Diabetes; Internal Medicine; Science, general;
• 出版者：Springer US
• ISSN：1559-0100

文摘

Only few studies have investigated to now whether the association with Turner syndrome (TS) may affect the course of Hashimoto’s thyroiditis (HT) in children. Aim of this study was to ascertain whether the presentation and long-term course of HT in TS children may be characterized by a peculiar and atypical pattern. The clinical and biochemical findings at HT diagnosis in 90 TS children (group A) were compared with those recorded in 449 girls with HT but without TS (group B); in group A patients, thyroid function tests were re-evaluated after a median time interval of 4.9 years. At HT diagnosis median TSH levels and the rate of cases presenting with a thyroid dysfunction picture were significantly lower in group A, irrespective of karyotype abnormalities. In group A only 34.8 % of the girls who had initially presented with euthyroidism remained euthyroid even at re-evaluation, whilst 67.7 % of those who had presented with subclinical hypothyroidism became overtly hypothyroid over time; also such evolutive pattern was irrespective of karyotype abnormalities. (1) In TS girls, HT presents with a milder hormonal pattern, which often deteriorates over time; (2) these biochemical features are not necessarily linked with a specific karyotype. Keywords Chromosomopathies Hyperthyroidism Overt hypothyroidism Subclinical hypothyroidism Thyroid autoimmune disease Thyroid function patterns