Cat scratch disease: analysis of 130 seropositive cases

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• 作者：Kyoko Murakami ; Masato Tsukahara ; Hidehiro Tsuneoka ; Hidechika Iino ; Chizuru Ishida ; Kumiko Tsujino ; Akiko Umeda ; Tomoko Furuya ; Shigeto Kawauchi and Kohsuke Sasaki
• 关键词：Key words  ; Cat scratch disease ; Bartonella henselae infection ; Indirect fluorescent antibody (IFA)
• 刊名：Journal of Infection and Chemotherapy
• 出版年：2002
• 出版时间：December 2002
• 年：2002
• 卷：8
• 期：4
• 页码：349-352
• 全文大小：283 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Infectious Diseases
  Oncology
  Internal Medicine
  
• 出版者：Springer Japan
• ISSN：1437-7780

文摘

 To clarify the clinical manifestations of cat scratch disease (CSD), we evaluated a total of 130 seropositive patients with CSD. The patients' ages ranged from 1 to 68 years; 103 (79.2%) were under 18 years of age. CSD occurred predominantly in the fall and winter months. Regional lymphadenopathy was noted in 110 (84.6%) of the cases, and the most common sites were the neck (33%), axillary (27%), and inguinal (18%) regions. One hundred of the patients (77%) had general symptoms, such as fever, headache, and malaise. The clinical manifestations of CSD showed a wide spectrum from typical or classical CSD, with regional lymphadenopathy, to atypical or systemic CSD. Of the 130 cases, 103 (79.2%) were typical CSD and 27 (20.8%) were atypical CSD. Atypical cases of CSD were commonly reported as fever of unknown origin (37.0%), neuroretinitis (22.2%), encehalopathy (14.8%), hepatosplenic granuloma (11.1%), and Parinaud's oculoglandular syndrome (7.4%). Fever of unknown origin or prolonged fever lasting more than 14 days was evident in 27 (20.8%) of the 130 cases in this study. Eleven of the 27 cases lacked lymphadenopathy. Our findings suggest that CSD is not a rare disease in Japan. The indirect fluorescent antibody (IFA) test to detect Bartonella species may provide a prompt diagnosis of CSD and facilitate appropriate therapy.