Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells

详细信息    查看全文

• 作者：Jun Fuchimoto (1) (2)
  Takashi Kojima (2)
  Tamaki Okabayashi (3)
  Tomoyuki Masaki (4)
  Noriko Ogasawara (4)
  Kazufumi Obata (2) (4)
  Kazuaki Nomura (2) (4)
  Satoshi Hirakawa (2) (5)
  Naoyuki Kobayashi (1)
  Tatsuro Shigyo (1)
  Shin-ichi Yokota (6)
  Nobuhiro Fujii (6)
  Hiroyuki Tsutsumi (5)
  Tetsuo Himi (4)
  Norimasa Sawada (2)
  
• 关键词：Humulone ; RSV ; Proinflammatory cytokine ; Chemokine ; Human nasal epithelial cells
• 刊名：Medical Molecular Morphology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：46
• 期：4
• 页码：203-209
• 全文大小：
• 作者单位：Jun Fuchimoto (1) (2)
  Takashi Kojima (2)
  Tamaki Okabayashi (3)
  Tomoyuki Masaki (4)
  Noriko Ogasawara (4)
  Kazufumi Obata (2) (4)
  Kazuaki Nomura (2) (4)
  Satoshi Hirakawa (2) (5)
  Naoyuki Kobayashi (1)
  Tatsuro Shigyo (1)
  Shin-ichi Yokota (6)
  Nobuhiro Fujii (6)
  Hiroyuki Tsutsumi (5)
  Tetsuo Himi (4)
  Norimasa Sawada (2)
  
  1. Frontier Laboratories of Value Creation, Sapporo Breweries Ltd, Shizuoka, 425-0013, Japan
  2. Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan
  3. Research Institute for Microbial Diseases, Osaka University, Suita, 565-0871, Japan
  4. Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan
  5. Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan
  6. Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan
  
• ISSN：1860-1499

文摘

Respiratory syncytial virus (RSV) is the major infectious agent causing serious respiratory tract inflammation in infants and young children. However, an effective vaccine and anti-viral therapy for RSV infection have not yet been developed. Hop-derived bitter acids have potent pharmacological effects on inflammation. Therefore, we investigated the effects of humulone, which is the main constituent of hop bitter acids, on the replication of RSV and release of the proinflammatory cytokine IL-8 and chemokine RANTES in RSV-infected human nasal epithelial cells (HNECs). We found that humulone prevented the expression of RSV/G-protein, formation of virus filaments and release of IL-8 and RANTES in a dose-dependent manner in RSV-infected HNECs. These findings suggest that humulone has protective effects against the replication of RSV, the virus assembly and the inflammatory responses in HNECs and that it is a useful biological product for the prevention and therapy for RSV infection.