The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

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• 作者：Akihisa Fujimoto (1) (2)
  Mari Ichinose (2)
  Miyuki Harada (2)
  Tetsuya Hirata (2)
  Yutaka Osuga (2)
  Tomoyuki Fujii (2)
  
• 关键词：Endometrial cancer ; Pregnancy ; ART ; Implantation ; Endometrial thickness
• 刊名：Journal of Assisted Reproduction and Genetics
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：31
• 期：9
• 页码：1189-1194
• 全文大小：180 KB
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  4. Dursun P, Erkanli S, Guzel AB, Gultekin M, Tarhan NC, Altundag O, et al. A Turkish Gynecologic Oncology Group study of fertility-sparing treatment for early-stage endometrial cancer. Int J Gynaecol Obstet. 2012;119:270鈥?. CrossRef
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  12. Zhang X, Chen CH, Confino E, Barnes R, Milad M, Kazer RR. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2005;83:336鈥?0. CrossRef
  13. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertil Steril. 2007;87:53鈥?. CrossRef
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  15. Shufaro Y, Simon A, Laufer N, Fatum M. Thin unresponsive endometrium鈥揳 possible complication of surgical curettage compromising ART outcome. J Assist Reprod Genet. 2008;25:421鈥?. CrossRef
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• 作者单位：Akihisa Fujimoto (1) (2)
  Mari Ichinose (2)
  Miyuki Harada (2)
  Tetsuya Hirata (2)
  Yutaka Osuga (2)
  Tomoyuki Fujii (2)
  
  1. Department of Obstetrics and Gynecology, Sanraku Hospital, 2-5, Kanda-Surugadai, Chiyoda-ku, Tokyo, Japan, 101-8326
  2. Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan, 113-8655
  
• ISSN：1573-7330

文摘

Purpose To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). Methods The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. Results There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. Conclusions Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.