Adenosquamous carcinoma of the tongue: clinicopathologic study and review of the literature

详细信息    查看全文

• 作者：Takafumi Satomi ; Michihide Kohno ; On Hasagawa ; Ai Enomoto ; Harutsugi Abukawa…
• 关键词：Adenosquamous carcinoma ; Tongue ; Immunohistochemical study ; Ultrastructural study
• 刊名：Odontology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：105
• 期：1
• 页码：127-135
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Dentistry; Oral and Maxillofacial Surgery;
• 出版者：Springer Japan
• ISSN：1618-1255
• 卷排序：105

文摘

Adenosquamous carcinoma (ASC) of the tongue is an uncommon malignant oral neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior. Here, we report a rare case of ASC of the lateral border of the tongue in a 65-year-old Japanese man. The patient was treated by radical operation and remained well for 6 months before developing metastasis of the hilar and pretracheal lymph nodes. Subsequently, the patient was treated with combined chemotherapy (nedaplatin plus docetaxel and S-1 for two cycles, intravenously) and radiotherapy. Radiation therapy of metastatic lymph nodes was performed at a total dose of 60 Gy and was delivered in 2 Gy fractions 5 days/week. The patient is currently tumor free and is being followed up carefully. This article describes a rare case of ASC of the tongue and its conventional histologic, immunohistochemical, and electron microscopic findings, together with a review of the literature. The findings provide important information to better understand the possible clinical and therapeutic approaches for this uncommon tumor of the tongue.