Exercise capacity in relation to autoantibodies in systemic sclerosis patients
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- 作者：Fujiko Someya (1)
Naoki Mugii (2)
Tetsutarou Yahata (2)
Takao Nakagawa (1) - 关键词：Systemic sclerosis ; 6 ; Min walking test ; Autoantibody ; Lung function ; Oxygen saturation
- 刊名：Rheumatology International
- 出版年：2013
- 出版时间：November 2013
- 年：2013
- 卷：33
- 期：11
- 页码：2913-2916
- 全文大小：
- 作者单位：Fujiko Someya (1)
Naoki Mugii (2)
Tetsutarou Yahata (2)
Takao Nakagawa (1)
1. School of Health Sciences, Kanazawa University, Kodatsuno 5-11-80, Kanazawa, 920-0942, Japan
2. Division of Rehabilitation, Kanazawa University Hospital, Takaramachi 13-1, Kanazawa, 920-8640, Japan - ISSN：1437-160X
文摘
Autoantibodies have been detected in systemic sclerosis patients, and typical clinical features regarding organ involvement by each autoantibody have been reported. To reveal differences in exercise intolerance in patients with either anti-topoisomerase-I or anti-centromere antibodies, 53 systemic sclerosis patients were investigated retrospectively. A 6-min walking distance showed no significant differences (P?=?0.090) between autoantibodies, while exercise-induced hypoxia during the 6-min walking test was significant in subjects with the anti-topoisomerase-I antibody (P?=?0.033). The percent predicted of vital capacity, the diffusion capacity of the lung for carbon monoxide, and the modified Rodnan skin score were affected more in subjects with the anti-topoisomerase-I antibody than the anti-centromere antibody. The main parameter affecting the 6-min walking distance was the percent predicted of vital capacity for each autoantibody, and there was a significant positive relationship for all subjects (R 2 ?=?0.30, P?<?0.0001). Exercise-induced hypoxia was also shown in the more affected subjects in the percent predicted of vital capacity and the diffusion capacity of the lung for carbon monoxide. Lung parameters were suggested to be more important factors determining exercise intolerance and induced hypoxia than detected autoantibodies.