Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis

详细信息    查看全文

• 作者：Elisa Damiani (1)
  Erica Adrario (1)
  Massimo Girardis (2)
  Rocco Romano (1)
  Paolo Pelaia (1)
  Mervyn Singer (3)
  Abele Donati (1)
  
  1. Anaesthesia and Intensive Care Unit ; Department of Biomedical Sciences and Public Health ; Universit脿 Politecnica delle Marche ; via Tronto 10 ; 60126 ; Torrette di Ancona ; Italy
  2. Department of Anaesthesia and Intensive Care ; University Hospital of Modena ; Via del Pozzo 71 ; 41124 ; Modena ; Italy
  3. Bloomsbury Institute of Intensive Care Medicine ; University College London ; Gower Street ; London ; WC1E 6BT ; UK
  
• 刊名：Critical Care
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：18
• 期：6
• 全文大小：961 KB
• 参考文献：1. Graaf, AE, Dongelmans, DA, Binnekade, JM, Jonge, E (2011) Clinicians鈥?response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2. Intensive Care Med 37: pp. 46-51 CrossRef
  2. Suzuki, S, Eastwood, GM, Peck, L, Glassford, NJ, Bellomo, R (2013) Current oxygen management in mechanically ventilated patients: a prospective observational cohort study. J Crit Care 28: pp. 647-654 CrossRef
  3. Dickstein, K, Cohen-Solal, A, Filippatos, G, McMurray, JJ, Ponikowski, P, Poole-Wilson, PA, Str枚mberg, A, Veldhuisen, DJ, Atar, D, Hoes, AW, Keren, A, Mebazaa, A, Nieminen, M, Priori, SG, Swedberg, K, Vahanian, A, Camm, J, Caterina, R, Dean, V, Dickstein, K, Filippatos, G, Funck-Brentano, C, Hellemans, I, Kristensen, SD, McGregor, K, Sechtem, U, Silber, S, Tendera, M (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the task force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the heart failure association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29: pp. 2388-2442 CrossRef
  4. Anderson, JL, Adams, CD, Antman, EM, Bridges, CR, Califf, RM, Casey, DE, Chavey, WE, Fesmire, FM, Hochman, JS, Levin, TN, Lincoff, AM, Peterson, ED, Theroux, P, Wenger, NK, Wright, RS, Smith, SC, Jacobs, AK, Adams, CD, Anderson, JL, Antman, EM, Halperin, JL, Hunt, SA, Krumholz, HM, Kushner, FG, Lytle, BW, Nishimura, R, Ornato, JP, Page, RL, Riegel, B (2007) ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: pp. e1-e157 CrossRef
  5. O鈥橠riscoll, R, Davison, A, Elliott, M, Howard, L, Wedzicha, J, Mackway-Jones, K, Jenkins, P, Kishen, R, Levy, M, Perrott, S, Mansfield, L, Evans, A, Panizzo, S, Moore, F, Whitmore, D, Gibbs, S, Martin, B, Hinshaw, K (2008) BTS guideline for emergency oxygen use in adult patients. Thorax 63: pp. vi1-68
  6. Peberdy, MA, Callaway, CW, Neumar, RW, Geocadin, RG, Zimmerman, JL, Donnino, M, Gabrielli, A, Silvers, SM, Zaritsky, AL, Merchant, R, Hoek, TL, Kronick, SL (2010) Part 9: post-cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010: pp. 768-786 CrossRef
  7. Kumaria, A, Tolias, CM (2009) Normobaric hyperoxia therapy for traumatic brain injury and stroke: a review. Br J Neurosurgery 23: pp. 576-584 CrossRef
  8. Menzel, M, Doppenberg, EM, Zauner, A, Soukup, J, Reinert, MM, Bullock, R (1999) Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 91: pp. 1-10 CrossRef
  9. Singhal, AB (2006) Oxygen therapy in stroke: past, present, and future. Int J Stroke 1: pp. 191-200 CrossRef
  10. Fracica, PJ, Knapp, MJ, Piantadosi, CA, Takeda, K, Fulkerson, WJ, Coleman, RE, Wolfe, WG, Crapo, JD (1991) Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology. J Appl Physiol 71: pp. 2352-2362
  11. Crapo, JD, Hayatdavoudi, G, Knapp, MJ, Fracica, PJ, Wolfe, WG, Piantadosi, CA (1994) Progressive alveolar septal injury in primates exposed to 60% oxygen for 14聽days. Am J Physiol 267: pp. L797-L806
  12. Altemeier, WA, Sinclair, SE (2007) Hyperoxia in the intensive care unit: why more is not always better. Curr Opin Crit Care 13: pp. 73-78 CrossRef
  13. Lodato, RF (1989) Decreased O2 consumption and cardiac output during normobaric hyperoxia in conscious dogs. J Appl Physiol 67: pp. 1551-1559
  14. Chan, PH (2001) Reactive oxygen radicals in signaling and damage in the ischaemic brain. J Cereb Blood Flow Metab 21: pp. 2-14 CrossRef
  15. Farquhar, H, Weatherall, M, Wijesinghe, M, Perrin, K, Ranchord, A, Simmonds, M, Beasley, R (2009) Systematic review of studies of the effect of hyperoxia on coronary blood flow. Am Heart J 158: pp. 371-377 CrossRef
  16. Jonge, E, Peelen, L, Keijzers, PJ, Joore, H, Lange, D, Voort, PHJ, Bosman, RJ, Waal, RAL, Wesselink, R, Keizer, NF (2008) Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care 12: pp. R156 CrossRef
  17. Kilgannon, JH, Jones, AE, Shapiro, NI, Angelos, MG, Milcarek, B, Hunter, K, Parrillo, JE (2010) Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 303: pp. 2165-2171 CrossRef
  18. Brenner, M, Stein, D, Hu, P, Kufera, J, Wooford, M, Scalea, T (2012) Association between early hyperoxia and worse outcome after traumatic brain injury. Arch Surg 147: pp. 1042-1046 CrossRef
  19. Rincon, F, Kang, J, Maltenfort, M, Vibbert, M, Urtecho, J, Athar, MK, Jallo, J, Pineda, CC, Tzeng, D, McBride, W, Bell, R (2014) Association between hyperoxia and mortality after stroke: a multicenter cohort study. Crit Care Med 42: pp. 387-396 CrossRef
  20. Eastwood, G, Bellomo, R, Bailey, M, Taori, G, Pilcher, D, Young, P, Beasley, R (2012) Arterial oxygen tension and mortality in mechanically ventilated patients. Intensive Care Med 38: pp. 91-98 CrossRef
  21. Bellomo, R, Bailey, M, Eastwood, GM, Nichol, A, Pilcher, D, Hart, GK, Reade, MC, Egi, M, Cooper, DJ (2011) Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care 15: pp. R90 CrossRef
  22. Raj, R, Bendel, S, Reinikainen, M, Kivisaari, R, Siironen, J, Lang, M, Skrifvars, M (2013) Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care 17: pp. R177 CrossRef
  23. Young, P, Beasly, R, Baily, M, Bellomo, R, Eastwood, GM, Nichol, A, Pilcher, DV, Yunos, MN, Egi, M, Hart, GK, Reade, MC, Cooper, DJ (2012) The association between early arterial oxygenation and mortality in ventilated patients with acute ischemic stroke. Crit Care Res 14: pp. 14-19
  24. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analysis: the PRISMA statement. PLOS Med 6: pp. e1000097 CrossRef
  25. Downs, SH, Black, N (1998) The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52: pp. 377-384 CrossRef
  26. Borenstein, M, Hedges, LV, Higgins, JPT, Rothstein, HR (2009) Introduction to Meta-Analysis. Chichester, UK, John Wiley and Sons, Ltd CrossRef
  ditors">Lipsey, MW, Wilson, DB eds. (2001) Practical Meta-Analysis. Sage, Thousand Oaks, CA
  27. Higgins, JPT, Thompson, SG, Deeks, JJ, Altman, DG (2003) Measuring inconsistency in meta-analysis. BMJ 327: pp. 557-560 CrossRef
  28. Sterne, JAC, Egger, M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54: pp. 1046-1055 CrossRef
  29. Kilgannon, JH, Jones, AE, Parrillo, JE, Dellinger, RP, Milcarek, B, Hunter, K, Shapiro, NI, Trzeciak, S (2011) Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation 123: pp. 2717-2722 CrossRef
  30. Ihle, JF, Bernard, S, Bailey, MJ, Pilcher, DV, Smith, K, Scheinkestel, CD (2013) Hyperoxia in the intensive care unit and outcome after out-of-hospital ventricular fibrillation cardiac arrest. Crit Care Resusc 15: pp. 186-190
  31. Suzuki, S, Eastwood, GM, Glassford, NJ, Peck, L, Young, H, Garcia-Alvarez, M, Schneider, AG, Bellomo, R (2014) Conservative oxygen therapy in mechanically ventilated patients: a pilot before-and-after trial. Crit Care Med 42: pp. 1414-1422 CrossRef
  32. Asher, SR, Curry, P, Sharma, D, Wang, J, O鈥橩eefe, GE, Daniel-Johnson, J, Vavilala, MS (2013) Survival advantage and PaO2 threshold in severe traumatic brain injury. J Neurosurg Anesthesiol 25: pp. 168-173 CrossRef
  33. Davis, DP, Meade, W, Sise, MJ, Kennedy, F, Simon, F, Tominaga, G, Steele, J, Coimbra, R (2009) Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma 26: pp. 2217-2223 CrossRef
  34. Janz, DR, Hollenbeck, RD, Pollock, JS, McPherson, JA, Rice, TW (2012) Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit Care Med 40: pp. 3135-3139 CrossRef
  35. Lee, BK, Jeung, KW, Lee, HY, Lee, SJ, Jung, YH, Lee, WK, Heo, T, Min, YI (2014) Association between mean arterial blood gas tension and outcome in cardiac arrest patients treated with therapeutic hypothermia. Am J Emerg Med 32: pp. 55-60 CrossRef
  36. Nelskyla, A, Parr, MJ, Skrifvars, MB (2013) Prevalence and factors correlating with hyperoxia exposure following cardiac arrest 鈥?an observational single centre study. Scan J Trauma Resusc Emerg Med 21: pp. 35 CrossRef
  37. Rincon, F, Kang, J, Vibbert, M, Urtecho, J, Athar, MK, Jallo, J (2014) Significance of arterial hyperoxia and relationship with case fatality in traumatic brain injury: a multicentre cohort study. J Neurol Neurosurg Psychiatry 85: pp. 799-805 CrossRef
  38. Wang, CH, Chang, WT, Huang, CH, Tsai, MS, Yu, PH, Wang, AY, Chen, NC, Chen, WJ (2014) The effect of hyperoxia on survival following adult cardiac arrest: a systematic review and meta-analysis of observational studies. Resuscitation 85: pp. 1142-1148 CrossRef
  39. Pilcher, J, Weatherall, M, Shirtcliffe, P, Bellomo, R, Young, P, Beasley, R (2012) The effect of hyperoxia following cardiac arrest 鈥?A systematic review and meta-analysis of animal trials. Resuscitation 83: pp. 417-422 CrossRef
  40. Kuisma, M, Boyd, J, Voipio, V, Alasp盲盲, A, Roine, RO, Rosenberg, P (2006) Comparison of 30 and the 100% inspired oxygen concentrations during early post-resuscitation period: a randomized controlled pilot study. Resuscitation 69: pp. 199-206 CrossRef
  41. Vaahersalo, J, Bendel, S, Reinikainen, M, Kurola, J, Tiainen, M, Raj, R, Pettila, V, Varpula, T, Skrifvars, MB (2014) Arterial blood gas tensions after resuscitation from out-of-hospital cardiac arrest: associations with long-term neurological outcome. Crit Care Med 42: pp. 1463-1470 CrossRef
  42. Iscoe, S, Beasley, R, Fisher, JA (2011) Supplementary oxygen for non-hypoxemic patients: O2 much of a good thing?. Crit Care 15: pp. 305 CrossRef
  43. Li, H, Forstermann, U (2013) Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease. Curr Opin Pharmacol 13: pp. 161-167 CrossRef
  44. Bourassa, MG, Campeau, L, Bois, MA, Rico, O (1969) The effects of inhalation of 100 percent oxygen on myocardial lactate metabolism in coronary heart disease. Am J Cardiol 24: pp. 172-177 CrossRef
  45. Rawles, JM, Kenmure, AC (1976) Controlled trial of oxygen in uncomplicated myocardial infarction. BMJ 1: pp. 1121-1123 CrossRef
  46. Singhal, AB, Benner, T, Roccatagliata, L, Koroshetz, WJ, Schaefer, PW, Lo, EH, Buonanno, FS, Gonzalez, RG, Sorensen, AG (2005) A pilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke 36: pp. 797-802 CrossRef
  47. Padma, MV, Bhasin, A, Bhatia, R, Garg, A, Singh, MB, Tripathi, M, Prasad, K (2010) Normobaric oxygen therapy in acute ischemic stroke: a pilot study in Indian patients. Ann Indian Acad Neurol 13: pp. 284-288 CrossRef
  48. Ronning, OM, Guldvog, B (1999) Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke 30: pp. 2033-2037 CrossRef
  49. Diringer, MN (2008) Hyperoxia 鈥?good or bad for the injured brain?. Curr Opin Crit Care 14: pp. 167-171 CrossRef
  50. Diringer, MN, Aiyagari, V, Zazulia, AR, Videen, TO, Powers, WJ (2007) Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury. J Neurosurg 106: pp. 526-529 CrossRef
  51. O鈥橠riscoll, BR, Howard, LS (2011) How to assess the dangers of hyperoxemia: methodological issues. Crit Care 15: pp. 435 CrossRef
  52. Cornet, AD, Kooter, AJ, Peters, MJL, Smulders, YM (2013) The potential harm of oxygen therapy in medical emergencies. Crit Care 17: pp. 313 CrossRef
  
• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：BioMed Central
• ISSN：1364-8535

文摘

Introduction The safety of arterial hyperoxia is under increasing scrutiny. We performed a systematic review of the literature to determine whether any association exists between arterial hyperoxia and mortality in critically ill patient subsets. Methods Medline, Thomson Reuters Web of Science and Scopus databases were searched from inception to June 2014. Observational or interventional studies evaluating the relationship between hyperoxia (defined as a supranormal arterial O2 tension) and mortality in adult intensive care unit (ICU) patients were included. Studies primarily involving patients with exacerbations of chronic pulmonary disease, acute lung injury and perioperative administration were excluded. Adjusted odds ratio (OR) of patients exposed versus those not exposed to hyperoxia were extracted, if available. Alternatively, unadjusted outcome data were recorded. Data on patients, study characteristics and the criteria used for defining hyperoxia exposure were also extracted. Random-effects models were used for quantitative synthesis of the data, with a primary outcome of hospital mortality. Results In total 17 studies (16 observational, 1 prospective before-after) were identified in different patient categories: mechanically ventilated ICU (number of studies (k) = 4, number of participants (n) = 189,143), post-cardiac arrest (k = 6, n = 19,144), stroke (k = 2, n = 5,537), and traumatic brain injury (k = 5, n = 7,488). Different criteria were used to define hyperoxia in terms of PaO2 value (first, highest, worst, mean), time of assessment and predetermined cutoffs. Data from studies on ICU patients were not pooled because of extreme heterogeneity (inconsistency (I2) 96.73%). Hyperoxia was associated with increased mortality in post-cardiac arrest patients (OR = 1.42 (1.04 to 1.92) I2 67.73%) stroke (OR = 1.23 (1.06 to 1.43) I2 0%) and traumatic brain injury (OR = 1.41 (1.03 to 1.94) I2 64.54%). However, these results are limited by significant heterogeneity between studies. Conclusions Hyperoxia may be associated with increased mortality in patients with stroke, traumatic brain injury and those resuscitated from cardiac arrest. However, these results are limited by the high heterogeneity of the included studies.