Narrowband ultraviolet B phototherapy ameliorates acute graft-versus-host disease by a mechanism involving in vivo expansion of CD4+CD25+Foxp3+ regulatory T cells
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- 作者：Satoshi Iyama (1)
Kazuyuki Murase (1)
Tsutomu Sato (1)
Akari Hashimoto (1)
Ayumi Tatekoshi (1)
Hiroto Horiguchi (1)
Yusuke Kamihara (1)
Kaoru Ono (1)
Shohei Kikuchi (1)
Kohichi Takada (1)
Yutaka Kawano (1)
Tsuyoshi Hayashi (1)
Koji Miyanishi (1)
Yasushi Sato (1)
Rishu Takimoto (1)
Masayoshi Kobune (1)
Satoru Mori (2)
Junji Kato (2)
Toshiharu Yamashita (2)
Junji Kato (1) - 关键词：Narrowband UVB ; GVHD ; Phototherapy ; Regulatory T cell
- 刊名：International Journal of Hematology
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：99
- 期：4
- 页码：471-476
- 全文大小：377 KB
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25. Larko O. Treatment of psoriasis with a new UVB-lamp. Acta Derm Venereol. 1989;69:357-. - 作者单位：Satoshi Iyama (1)
Kazuyuki Murase (1)
Tsutomu Sato (1)
Akari Hashimoto (1)
Ayumi Tatekoshi (1)
Hiroto Horiguchi (1)
Yusuke Kamihara (1)
Kaoru Ono (1)
Shohei Kikuchi (1)
Kohichi Takada (1)
Yutaka Kawano (1)
Tsuyoshi Hayashi (1)
Koji Miyanishi (1)
Yasushi Sato (1)
Rishu Takimoto (1)
Masayoshi Kobune (1)
Satoru Mori (2)
Junji Kato (2)
Toshiharu Yamashita (2)
Junji Kato (1)
1. Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine, South-1 West-16, Chuo-ku, Sapporo, Japan
2. Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan - ISSN：1865-3774
文摘
Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement of indirect effects on systemic immunity has not been elucidated. To address this issue, 11 acute skin GVHD patients refractory to standard corticosteroid treatment and with no gut/liver involvement were treated with NB-UVB irradiation. The median number of treatments was 10 times, with a mean cumulative exposure of 6.36?J/cm2. No other immunosuppressive therapy was initiated during irradiation. Eight patients achieved an objective complete response, two had a partial response, and one showed no change. None of the patients experienced progressive skin GVHD or newly diagnosed gut/liver GVHD. NB-UVB was well tolerated, with no patients discontinuing irradiation due to toxicity. We additionally demonstrated by flow cytometry that NB-UVB irradiation induces the increment of the proportion of regulatory T cell (Tregs) in patients-peripheral blood. These results suggest that NB-UVB may exert beneficial effects on steroid-refractory skin GVHD through the expansion of Tregs.