Dectin-2-dependent host defense in mice infected with serotype 3 Streptococcus pneumoniae

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• 作者：Yukiko Akahori ; Tomomitsu Miyasaka ; Masahiko Toyama ; Ikumi Matsumoto…
• 关键词：Streptococcus pneumonia ; Dectin ; 2 ; Neutrophils ; Anti ; capsular polysaccharide IgG ; IFN ; γ
• 刊名：BMC Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,086 KB
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• 作者单位：Yukiko Akahori (1) (5)
  Tomomitsu Miyasaka (1) (6)
  Masahiko Toyama (1) (7)
  Ikumi Matsumoto (1)
  Anna Miyahara (1)
  Tong Zong (1)
  Keiko Ishii (1)
  Yuki Kinjo (2)
  Yoshitsugu Miyazaki (2)
  Shinobu Saijo (3)
  Yoichiro Iwakura (4)
  Kazuyoshi Kawakami (1)
  
  1. Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Miyagi, Japan
  5. Present address: Japanese Red Cross Society, Tokyo, Japan
  6. Present address: Department of Pathophysiology, Tohoku Pharmaceutical University, Miyagi, Japan
  7. Present address: Ibaraki Prefectural Hospital, Ibaraki, Japan
  2. Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan
  3. Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan
  4. Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan
  
• 刊物主题：Immunology; Allergology; Vaccine; Cytokines and Growth Factors;
• 出版者：BioMed Central
• ISSN：1471-2172

文摘

Background Streptococcus pneumoniae, a major causative bacterial pathogen of community-acquired pneumonia, possesses a thick polysaccharide capsule. Host defense against this bacterium is mediated by activation of innate immune cells that sense bacterial components. Recently, C-type lectin receptors (CLRs) have garnered much attention in elucidating the recognition mechanism of pathogen-derived polysaccharides.