A randomized, placebo-controlled trial of d-cycloserine for the enhancement of social skills training in autism spectrum disorders

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• 作者：Noha F. Minshawi ; Logan K. Wink ; Rebecca Shaffer ; Martin H. Plawecki…
• 关键词：d ; cycloserine ; Autism spectrum disorders ; Social skills training ; Social deficits
• 刊名：Molecular Autism
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：7
• 期：1
• 全文大小：501 KB
• 参考文献：1.Kanner L. Autistic disturbances of affective contact. Nervous Child. 1943;2:217–50.
  2.CDC. Prevalence of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, Contract No.: 2. 2010.
  3.Wink LK, Erickson CA, McDougle CJ. Pharmacologic treatment of behavioral symptoms associated with autism and other pervasive developmental disorders. Curr Treat Options Neurol. 2010;12(6):529–38. doi:10.​1007/​s11940-010-0091-8 .PubMed CrossRef
  4.Blankenship K, Stigler KA, Erickson CA, Posey DJ, McDougle CJ. Psychopharmacoloigcal treatment of autism. In: Amaral D, Dawson G, Geschwind D, editors. Autism spectrum disorders. New York: Oxford University Press; 2011. p. 1194–212.
  5.Posey DJ, Erickson CA, McDougle CJ. Developing drugs for core social and communication impairment in autism. Child Adolesc Psychiatr Clin N Am. 2008;17(4):787–801. doi:10.​1016/​j.​chc.​2008.​06.​010 . viii-ix.PubMed PubMedCentral CrossRef
  6.Magiati I, Tay XW, Howlin P. Cognitive, language, social and behavioural outcomes in adults with autism spectrum disorders: a systematic review of longitudinal follow-up studies in adulthood. Clin Psychol Rev. 2014;34(1):73–86.PubMed CrossRef
  7.McDougle CJ, Erickson CA, Stigler KA, Posey DJ. Neurochemistry in the pathophysiology of autism. J Clin Psychiatry. 2005;66 Suppl 10:9–18.PubMed
  8.Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, et al. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry. 1999;56(1):21–7.PubMed CrossRef
  9.van Berckel BN, Evenblij CN, van Loon BJ, Maas MF, van der Geld MA, Wynne HJ, et al. D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: a double-blind, parallel, placebo-controlled study. Neuropsychopharmacology. 1999;21(2):203–10. doi:10.​1016/​s0893-133x(99)00014-7 .PubMed CrossRef
  10.Goff DC, Cather C, Gottlieb JD, Evins AE, Walsh J, Raeke L, et al. Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: an exploratory study. Schizophr Res. 2008;106(2–3):320–7. doi:10.​1016/​j.​schres.​2008.​08.​012 .PubMed PubMedCentral CrossRef
  11.Goff DC, Herz L, Posever T, Shih V, Tsai G, Henderson DC, et al. A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients. Psychopharmacology. 2005;179(1):144–50. doi:10.​1007/​s00213-004-2032-2 .PubMed CrossRef
  12.Duncan EJ, Szilagyi S, Schwartz MP, Bugarski-Kirola D, Kunzova A, Negi S, et al. Effects of D-cycloserine on negative symptoms in schizophrenia. Schizophr Res. 2004;71(2–3):239–48. doi:10.​1016/​j.​schres.​2004.​03.​013 .PubMed CrossRef
  13.Posey DJ, Kem DL, Swiezy NB, Sweeten TL, Wiegand RE, McDougle CJ. A pilot study of D-cycloserine in subjects with autistic disorder. Am J Psychiatry. 2004;161(11):2115–7. doi:10.​1176/​appi.​ajp.​161.​11.​2115 .PubMed CrossRef
  14.Posey DJ, Stigler KA, Erickson CA, Azzouz F, Wilkerson J, Mullett J, et al., editors. A double-blind, placebo-controlled study of D-cycloserine in children with autistic disorder, American College of Neuropsychopharmacology 46th Annual Meeting 2007 December 9–13. Boca Raton: American College of Neuropsychopharmacology; 2007.
  15.Swanson CJ, Bures M, Johnson MP, Linden A-M, Monn JA, Schoepp DD. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov. 2005;4(2):131–44.PubMed CrossRef
  16.Cortese BM, Phan KL. The role of glutamate in anxiety and related disorders. CNS Spectrums. 2005;10(10):820–30.PubMed
  17.Norberg MM, Krystal JH, Tolin DF. A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry. 2008;63(12):1118–26. doi:10.​1016/​j.​biopsych.​2008.​01.​012 .PubMed CrossRef
  18.Rodrigues H, Figueira I, Lopes A, Goncalves R, Mendlowicz MV, Coutinho ES, et al. Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS One. 2014;9(7), e93519. doi:10.​1371/​journal.​pone.​0093519 .PubMed PubMedCentral CrossRef
  19.Modi ME, Young LJ. D-cycloserine facilitates socially reinforced learning in an animal model relevant to autism spectrum disorders. Biol Psychiatry. 2011;70(3):298–304. doi:10.​1016/​j.​biopsych.​2011.​01.​026 .PubMed PubMedCentral CrossRef
  20.Foxx RM. Applied behavior analysis treatment of autism: the state of the art. Child Adolesc Psychiatr Clin N Am. 2008;17(4):821–34.PubMed CrossRef
  21.Scattone D, Tingstrom DH, Wilczynski SM. Increasing appropriate social interactions of children with autism spectrum disorders using social stories. Focus Autism Other Developmental Disabilities. 2006;21(4):211–22. doi:10.​1177/​1088357606021004​0201 .CrossRef
  22.Schneider N, Goldstein H. Using social stories and visual schedules to improve socially appropriate behaviors in children with autism. J Posit Behav Interv. 2010;12(3):149–60.CrossRef
  23.Koegel L, Vernon T, Koegel RL, Koegel B, Paullin AW. Improving socialization between children with autism spectrum disorder and their peers in inclusive settings. J Posit Behav Interv. 2012;14(4):220–7.PubMed PubMedCentral CrossRef
  24.Reichow B, Volkmar FR. Social skills interventions for individuals with autism: evaluation for evidence-based practices within a best evidence synthesis framework. J Autism Dev Disord. 2010;40:149–66.PubMed CrossRef
  25.Stone W, Ruble L, Coonrod E, Hepburn S, Pennington M. TRIAD social skills assessment manual. Nashville, TN: Treatment and Research Institute for Autism Spectrum Disorders; 2003.
  26.Pozdol SL SN, Stuart ML, Beach EB, Beach EB, editors. Social skills training in children with ASD: a comparison of weekly groups and summer camp formats. Annual convention of the association for behavior analysis. Social skills training in children with ASD: a comparison of weekly groups and summer camp formats. Annual convention of the Association for Behavior Analysisth ed. San Diego: Association for Behavior Analysis; 2007.
  27.Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L, et al. Autism diagnostic observation schedule: a standardized observation of communicative and social behavior. J Autism Dev Disord. 1989;19(2):185–212.PubMed CrossRef
  28.Gotham K, Risi S, Pickles A, Lord C. The autism diagnostic observation schedule: revised algorithms for improved diagnostic validity. J Autism Dev Disord. 2007;37(4):613–27. doi:10.​1007/​s10803-006-0280-1 .PubMed CrossRef
  29.Lord C, Pickles A, McLennan J, Rutter M, Bregman J, Folstein S, et al. Diagnosing autism: analyses of data from the autism diagnostic interview. J Autism Dev Disord. 1997;27(5):501–17.PubMed CrossRef
  30.Association AP. Diagnostic and statistical manual of mental disorders, fourth edition, text revision. Washington, DC: American Psychiatric Association; 2000.CrossRef
  31.Roid GH. Stanford-Binet intelligence scales for early childhood, Early SB5. Fifthth ed. 2005.
  32.Sparrow SS, Cicchetti DV, Balla DA. Vineland adaptive behavior scales, Vineland-II. Secondth ed. 2008.
  33.Constantino JN, Gruber CP. Social responsiveness scale. 2005.
  34.Sprafkin J, Gadow KD. Child symptom inventory 4. 2002.
  35.Marrus N, Underwood-Riordan H, Randall F, Zhang Y, Constantino JN. Lack of effect of risperidone on core autistic symptoms: data from a longitudinal study. J Autism Dev Disord. 2014;24(9):513–8. doi:10.​1089/​cap.​2014.​0055 .
  36.Lyall K, Constantino JN, Weisskopf MG, Roberts AL, Ascherio A, Santangelo SL. Parental social responsiveness and risk of autism spectrum disorder in offspring. JAMA Psychiatry. 2014;71(8):936–42. doi:10.​1001/​jamapsychiatry.​2014.​476 .PubMed PubMedCentral CrossRef
  37.Erickson CA, Veenstra-Vanderweele JM, Melmed RD, McCracken JT, Ginsberg LD, Sikich L, et al. STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study. J Autism Dev Disord. 2014;44(4):958–64. doi:10.​1007/​s10803-013-1963-z .PubMed CrossRef
  38.Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry. 2012;71(11):956–61. doi:10.​1016/​j.​biopsych.​2012.​01.​014 .PubMed CrossRef
  39.Aman MG, Singh NN. Aberrant behavior checklist, ABC. 1986.
  40.Fisch GS. Adaptive behavior in children with autism. J Autism Dev Disord. 2001;31(2):249.PubMed CrossRef
  41.Freeman BJ, Del’Homme M, Guthrie D, Zhang F. Vineland adaptive behavior scale scores as a function of age and initial IQ in 210 autistic children. J Autism Dev Disord. 1999;29(5):379–84.PubMed CrossRef
  42.McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, et al. Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002;347(5):314–21. doi:10.​1056/​NEJMoa013171 .PubMed CrossRef
  43.Murray DS, Ruble LA, Willis H, Molloy CA. Parent and teacher report of social skills in children with autism spectrum disorders. Lang Speech Hear Serv Sch. 2009;40(2):109–15.PubMed CrossRef
  44.Ruble L, Willis H, Crabtree VM. Social skills group therapy for autism spectrum disorders. Clinical Case Studies. 2008;7(4):287–300.CrossRef
  45.Guastella AJ, Gray KM, Rinehart NJ, Alvares GA, Tonge BJ, Hickie IB, et al. The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial. J Child Psychol Psychiatry. 2015;56(4):444–52. doi:10.​1111/​jcpp.​12305 .PubMed CrossRef
  46.American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5™ (5th ed.). Arlington, VA, US: American Psychiatric Publishing, Inc.; 2013.
  47.Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004;61(11):1136–44. doi:10.​1001/​archpsyc.​61.​11.​1136 .PubMed CrossRef
  48.Hofmann SG, Meuret AE, Smits JA, Simon NM, Pollack MH, Eisenmenger K, et al. Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Arch Gen Psychiatry. 2006;63(3):298–304. doi:10.​1001/​archpsyc.​63.​3.​298 .PubMed CrossRef
  49.Gresham FM, Elliot SN. Social Skills Improvement system-rating scales. Minneapolis: Pearson Assessments; 2008.
  
• 作者单位：Noha F. Minshawi (1)
  Logan K. Wink (2)
  Rebecca Shaffer (2)
  Martin H. Plawecki (1)
  David J. Posey (3)
  Hai Liu (4)
  Sarah Hurwitz (5)
  Christopher J. McDougle (6)
  Naomi B. Swiezy (1)
  Craig A. Erickson (2)
  
  1. Christian Sarkine Autism Treatment Center, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine Department of Psychiatry, Indianapolis, IN, USA
  2. Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA
  3. David J. Posey, M.D., LLC, Indianapolis, IN, USA
  4. Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
  5. Indiana University School of Education, Bloomington, IN, USA
  6. Lurie Center for Autism, Departments of Psychiatry and Pediatrics, Massachusetts General Hospital and MassGeneral Hospital for Children, Harvard Medical School, Boston, MA, USA
  
• 刊物主题：Neurology; Neurosciences; Neuropsychology; Molecular Medicine; Psychiatry; Pediatrics;
• 出版者：BioMed Central
• ISSN：2040-2392

文摘

Background Researchers have demonstrated that d-cycloserine (DCS) can enhance the effects of behavioral interventions in adults with anxiety and enhances prosocial behavior in animal models of autism spectrum disorders (ASD). This study extended upon this background by combining DCS with behavioral social skills therapy in youth with ASD to assess its impact on the core social deficits of ASD. We hypothesized that DCS used in combination with social skills training would enhance the acquisition of social skills in children with ASD.