Effects of methanolic fruit extract of Solanum macrocarpum L. (Solanaceae) on biochemical profile of albino rats (Rattus norvegicus)

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• 作者：Chiemekam Samuel Ezechukwu ; Vincent Chikwendu Ejere…
• 关键词：Solanum macrocarpum ; Lipid profile ; Liver markers ; Kidney markers ; Rats
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：25
• 期：1
• 页码：67-73
• 全文大小：283 KB
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• 作者单位：Chiemekam Samuel Ezechukwu (1)
  Vincent Chikwendu Ejere (1)
  Edmund Chidiebere Mbegbu (2)
  Godwin Chigozie Ugwu (1)
  Emmanuel Ikechukwu Nnamonu (1)
  
  1. Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria
  2. Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

The effects of methanolic fruit extract of Solanum macrocarpum on the biochemical parameters of normal albino rats were investigated for 21 days. Forty-eight (48) adult male albino rats were divided into a control group (A) and three treatment groups (B, C and D) of 12 rats each. Each group was further divided into three replicates of four rats each. Groups B, C and D received daily oral administration of the extract at doses of 400, 800 and 1600 mg/kg of body weight (bw), respectively, while the control group received distilled water for 21 days. Blood samples were collected before the start of experimentation (week 0) and thereafter at weekly intervals from one rat per replicate. Biochemical parameters of the blood samples were determined using bioassay. All the treatment groups showed a progressive significant reduction in serum total cholesterol levels from week 0 to week 3. Similarly, there was significant decrease (p < 0.05) in very low-density lipoprotein (VLDL) cholesterol and triglyceride serum levels of the treatment groups in week 3. The treatment doses generally showed a non-significant decrease (p > 0.05) in aspartate transaminase (AST), a significant decrease (p < 0.05) in alanine transaminase (ALT) levels and non-significant increase (p > 0.05) in bilirubin. There was non-significant decrease in albumin levels of the treated rats across weeks, while total protein showed a non-significant increase. The urea and blood urea nitrogen (BUN) and creatinine levels of the treated rats showed an overall non-significant (p > 0.05) increase. This study suggests that methanolic fruit extract of S. macrocarpum may be useful in reducing serum cholesterol levels. Keywords Solanum macrocarpum Lipid profile Liver markers Kidney markers Rats