Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice
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- 作者：Suelen S. da Silva ; Sandra S. Mizokami ; Jacqueline R. Fanti…
- 关键词：Leishmania amazonensis ; Propolis ; Liver ; Glucantime ; Inflammation
- 刊名：Parasitology Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：115
- 期：4
- 页码：1557-1566
- 全文大小：847 KB
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Sandra S. Mizokami (1)
Jacqueline R. Fanti (1)
Milena M. Miranda (1)
Natalia Y. Kawakami (1)
Fernanda Humel Teixeira (2)
Eduardo J. A. Araújo (2)
Carolina Panis (3)
Maria A. E. Watanabe (1)
José M. Sforcin (4)
Wander R. Pavanelli (1)
Waldiceu A. Verri Jr (1)
Ionice Felipe (1)
Ivete Conchon-Costa (1)
1. Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, 86057-970, Paraná, Brazil
2. Departamento de Histologia, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, 86057-970, Paraná, Brazil
3. Laboratório de Mediadores Inflamatórios, Universidade do Oeste do Paraná, UNIOESTE, Francisco Beltrão, 85605-010, Paraná, Brazil
4. Departamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista, UNESP, Botucatu, 18618-970, São Paulo, Brazil - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Medical Microbiology
Microbiology
Immunology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1955
文摘
Experimental models of mouse paw infection with L. amazonensis show an induction of a strong inflammatory response in the skin, and parasitic migration may occur to secondary organs with consequent tissue injury. There are few studies focusing on the resolution of damage in secondary organs caused by Leishmania species-related cutaneous leishmaniasis. We investigated the propolis treatment effect on liver inflammation induced by Leishmania amazonensis infection in the mouse paw. BALB/c mice were infected in the hind paw with L. amazonensis (107) promastigote forms. After 15 days, animals were treated daily with propolis (5 mg/kg), Glucantime (10 mg/kg), or with propolis plus Glucantime combined. After 60 days, mice were euthanized and livers were collected for inflammatory process analysis. Liver microscopic analysis showed that propolis reduced the inflammatory process compared to untreated infected control. There was a decrease of liver myeloperoxidase and N-acetyl-β-glucosaminidase activity levels, collagen fiber deposition, pro-inflammatory cytokine production, and plasma aspartate transaminase and alanine transaminase levels. Furthermore, propolis treatment enhanced anti-inflammatory cytokine levels and reversed hepatosplenomegaly. Our data demonstrated that daily low doses of Brazilian propolis reduced the secondary chronic inflammatory process in the liver caused by L. amazonensis subcutaneous infection in a susceptible mice strain.