Understanding the regulation of coding and noncoding transcription in cell populations

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• 作者：Traude Helene Beilharz
• 关键词：Gene expression ; RNA metabolism ; 3′-End formation ; Noncoding RNA ; Convergent antisense transcription
• 刊名：Current Genetics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：62
• 期：2
• 页码：317-319
• 全文大小：391 KB
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• 作者单位：Traude Helene Beilharz (1)
  
  1. Development and Stem Cells Program, Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbial Genetics and Genomics
  Microbiology
  Biochemistry
  Cell Biology
  Plant Sciences
  Proteomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0983

文摘

Whole transcriptome analyses have unveiled the uncomfortable truth that we know less about how transcription is regulated then we thought. In addition to its role in classic promoter-driven transcription of coding RNA, it is now clear that RNA Pol II also drives abundant expression of noncoding RNA. For the majority of this the functional significance remains unclear. Moreover, its regulation and impact are hard to predict because it often proceeds in unexpected ways from cryptic promoters, including by driving convergent antisense transcription from within 3′ UTRs. This review suggests that its time to rethink how we envisage gene expression by inclusion of the regulatory architecture of the full genetic locus, and expanding our thinking to encompass the fact that we generally study cells within heterogeneous populations.