Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment

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• 作者：Byung-Hak Kim ; Eun Hee Yi ; Sang-Kyu Ye
• 关键词：Cancer ; Inflammation ; Signal transducer and activator of transcription 3 (STAT3) ; Tumor microenvironment
• 刊名：Archives of Pharmacal Research
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：39
• 期：8
• 页码：1085-1099
• 全文大小：1,700 KB
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786
• 卷排序：39

文摘

Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that modulates the transcription of a variety of genes to regulate important biological functions, including cell proliferation, differentiation, survival, angiogenesis, and immune response. Constitutive activation of STAT3 is important in oncogenic signaling and occurs at high frequency in human cancers, including diverse solid tumors and hematologic malignancies. Moreover, it is associated with a poor prognosis. The tumor microenvironment has recently been recognized as a key condition for cancer progression, invasion, angiogenesis, metastasis, and drug resistance by activation of STAT3 signaling. Therefore, understanding the biology associated with STAT3-mediated signaling cascades in the tumor microenvironment may offer the therapeutic potential to treat human cancers. This review presents an overview of the critical roles of STAT3 in the tumor microenvironment related to cancer biology and discusses recent advancements in the development of anticancer drugs that therapeutically inhibit STAT3 signaling cascades.