Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice
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- 作者：Doris Kaltenecker ; Kristina M. Mueller ; Pia Benedikt ; Ursula Feiler…
- 关键词：Adipose tissue ; Energy metabolism ; Lipolysis ; STAT5
- 刊名：Diabetologia
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：60
- 期：2
- 页码：296-305
- 全文大小：1403KB
- 刊物类别：Medicine
- 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0428
- 卷排序：60
文摘
Aims/hypothesisDysfunction of lipid metabolism in white adipose tissue can substantially interfere with health and quality of life, for example in obesity and associated metabolic diseases. Therefore, it is important to characterise pathways that regulate lipid handling in adipocytes and determine how they affect metabolic homeostasis. Components of the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway are involved in adipocyte physiology and pathophysiology. However, the exact physiological importance of the STAT family member STAT5 in white adipose tissue is yet to be determined. Here, we aimed to delineate adipocyte STAT5 functions in the context of lipid metabolism in white adipose tissue.