Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

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• 作者：Maria A. van Agthoven ; Mark P. Barrow…
• 关键词：FT ; ICR MS ; Fourier transform ion cyclotron resonance mass spectrometry ; Two ; dimensional ; IRMPD ; Infrared multiphoton dissociation ; APPI ; Atmospheric pressure photoionization ; Cholesterol
• 刊名：Journal of The American Society for Mass Spectrometry
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：26
• 期：12
• 页码：2105-2114
• 全文大小：1,141 KB
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• 作者单位：Maria A. van Agthoven (1)
  Mark P. Barrow (1)
  Lionel Chiron (2)
  Marie-Aude Coutouly (2)
  David Kilgour (3)
  Christopher A. Wootton (1)
  Juan Wei (1)
  Andrew Soulby (1)
  Marc-Andr茅 Delsuc (2) (4)
  Christian Rolando (5)
  Peter B. O鈥機onnor (1)
  
  1. Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
  2. NMRTEC, Bld. S茅bastien Brandt, Bioparc - Bat. B, 67400, Illkirch-Graffenstaden, France
  3. School of Pharmacy, University of Maryland, Baltimore, MD, 21201, USA
  4. Institut de G茅n茅tique et de Biologie Mol茅culaire et Cellulaire, INSERM, U596; CNRS, UMR7104, Universit茅 de Strasbourg, 1 rue Laurent Fries, 67404, Illkirch-Graffenstaden, France
  5. Miniaturisation pour la Synth猫se, l鈥橝nalyse & la Prot茅omique (MSAP), USR CNRS 3290, and Prot茅omique, Modifications Post-traductionnelles et Glycobiologie, IFR 147 and Institut Eug猫ne-Michel Chevreul, FR CNRS 2638, Universit茅 de Lille 1 Sciences et Technologies, 59655, Villeneuve d鈥橝scq Cedex, France
  
• 刊物主题：Analytical Chemistry; Biotechnology; Organic Chemistry; Proteomics; Bioinformatics;
• 出版者：Springer US
• ISSN：1879-1123

文摘

Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry is a data-independent analytical method that records the fragmentation patterns of all the compounds in a sample. This study shows the implementation of atmospheric pressure photoionization with two-dimensional (2D) Fourier transform ion cyclotron resonance mass spectrometry. In the resulting 2D mass spectrum, the fragmentation patterns of the radical and protonated species from cholesterol are differentiated. This study shows the use of fragment ion lines, precursor ion lines, and neutral loss lines in the 2D mass spectrum to determine fragmentation mechanisms of known compounds and to gain information on unknown ion species in the spectrum. In concert with high resolution mass spectrometry, 2D Fourier transform ion cyclotron resonance mass spectrometry can be a useful tool for the structural analysis of small molecules.