Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
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- 作者：David J. Duffy ; Aleksandar Krstic ; Melinda Halasz ; Thomas Schwarzl…
- 关键词：Neuroblastoma ; Kartogenin (KGN) ; RepSox ; MYC (c ; MYC) ; Differentiation ; mRNA sequencing (mRNA ; seq) ; ChIP sequencing (ChIP ; seq) ; Transforming growth factor beta (TGF ; β) signalling ; Interaction proteomics ; Precision medicine ; Genome medicine ; Wnt β ; catenin signalling ; Cancer ; Systems medicine ; Neuronal differentiation ; Differentiation therapy
- 刊名：Genome Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：3109KB
- 刊物主题：Human Genetics; Metabolomics; Bioinformatics; Medicine/Public Health, general; Cancer Research; Systems Biology;
- 出版者：BioMed Central
- ISSN：1756-994X
- 卷排序：9
文摘
BackgroundRetinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a precision medicine approach to globally profile the retinoid signalling response and to determine how an excess of cellular MYCN antagonises these signalling events to prevent differentiation and confer resistance.