Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging
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- 作者：Jason T. Lee ; Hanwen Zhang ; Maxim A. Moroz ; Yury Likar…
- 关键词：Key wordsHuman reporter gene imaging ; Deoxycytidine kinase ; Thymidine kinase ; [18F]FEAU ; l ; [18F]FEAU ; l ; [18F]FMAU ; [14C]FMAU ; [124I]FIAU ; Gene and cell therapy ; Immunotherapy
- 刊名：Molecular Imaging and Biology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：19
- 期：1
- 页码：100-108
- 全文大小：
- 刊物主题：Imaging / Radiology;
- 出版者：Springer US
- ISSN：1860-2002
- 卷排序：19
文摘
PurposeRadionuclide-based reporter gene imaging has the sensitivity to monitor gene- and cell-based therapies in human subjects. Potential immunogenicity of current viral transgenes warrants development of human-based reporter systems. We compared human nucleoside kinase reporters to a panel of nucleoside analogs of FEAU, FMAU, and FIAU, including the first in vivo assessment of l-[18F]FEAU.