Genetic engineering of Plum pox virus resistance: ‘HoneySweet-plum—from concept to product
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- 作者：Ralph Scorza (1)
Ann Callahan (1)
Chris Dardick (1)
Michel Ravelonandro (2)
Jaroslav Polak (3)
Tadeusz Malinowski (4)
Ioan Zagrai (5)
Mariano Cambra (6)
Ivanka Kamenova (7) - 关键词：Fruit breeding ; Genetic engineering regulation ; Genetic Modification ; Pathogen ; derived resistance ; Plum ; Prunus domestica ; Rapid cycle breeding ; Risk assessment ; RNAi ; siRNA ; Rosaceae ; Sharka ; Transgenic plants
- 刊名：Plant Cell, Tissue and Organ Culture
- 出版年：2013
- 出版时间：October 2013
- 年：2013
- 卷：115
- 期：1
- 页码：1-12
- 全文大小：416KB
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Ann Callahan (1)
Chris Dardick (1)
Michel Ravelonandro (2)
Jaroslav Polak (3)
Tadeusz Malinowski (4)
Ioan Zagrai (5)
Mariano Cambra (6)
Ivanka Kamenova (7)
1. Agricultural Research Service-Appalachian Fruit Research Station, United States Department of Agriculture, Kearneysville, WV, USA
2. UMR 1332 Biologie du Fruit et Pathologie, INRA-bordeaux, Villenave D’Ornon Cedex, France
3. Crop Research Institute, Prague, Czech Republic
4. Institute of Horticulture, Skierniewice, Poland
5. Fruit Research and Development Station Bistrita, Bistrita, Romania
6. Instituto Valenciano de Investigaciones Agraria (IVIA), Moncada, Valencia, Spain
7. AgroBioInstitute, Sofia, Bulgaria
文摘
Sharka disease, caused by Plum pox virus (PPV) was first recorded in Bulgaria during the early twentieth century and since that first report, the disease has progressively spread throughout Europe and more recently to Asia, Africa, North and South America. Few PPV resistance genes have been found to naturally occur in Prunus and this has led to the investigation of biotech approaches to the development of resistance through genetic engineering (GE). A notable example of the utility of this approach is ‘HoneySweet-plum. PPV protection in this case is based on RNA interference (RNAi) and resistance has been shown to be highly effective, stable, durable, and heritable as a dominant trait. Extensive testing and risk assessment of ‘HoneySweet-in laboratory, greenhouse and in the field for over 20?years has demonstrated not only the effectiveness but also the safety of the technology. ‘HoneySweet-has been cleared for cultivation in the USA. By the appropriate regulatory agencies. The development and regulatory approval of ‘HoneySweet-demonstrate the ability of RNAi technology to contribute to the sustainability of stone fruit production in regions impacted by PPV. Although it has taken almost 100?years since the identification of sharka, we are now able to effectively protect stone fruit species against this disease through the application of GE.