Tissue transglutaminase and the stress response

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• 作者：R. Ientile ; D. Caccamo and M. Griffin
• 关键词：Keywords ; Transglutaminases &#8211 ; Tissue transglutaminase &#8211 ; Neurodegeneration &#8211 ; Oxidative stress &#8211 ; Inflammation &#8211 ; Extracellular matrix
• 刊名：Amino Acids
• 出版年：2007
• 出版时间：August, 2007
• 年：2007
• 卷：33
• 期：2
• 页码：385-394
• 全文大小：162 KB

文摘

The expression of the protein crosslinking enzyme tissue transglutaminase (TG2, tTG), the ubiquitous member of transglutaminase family, can be regulated by multiple factors. Although it has been suggested that TG2 can be involved in apoptotic cell death, high levels of enzyme have also been associated with cell survival in response to different stimuli. Furthermore, evidence indicates that increases in TG2 production cause enzyme translocation to cell membrane. Cell stress can also lead to TG2 accumulation on the cell surface and in the extracellular matrix resulting in changes in cell-matrix interactions. Here, we discuss the underlying mechanisms of TG2 up-regulation induced by various stimuli including glutamate exposure, calcium influx, oxidative stress, UV, and inflammatory cytokines.